In a recent neuropathologic
study there was no significant loss of tyrosine hydroxylase positive neurons in the substantia nigra in normal subjects (44-80 years of age).
analysis in the five definite cases with available brain tissue specimens was diagnostic of classic CJD; none had the characteristic pathologic findings of vCJD.
examination of the remaining 2 mice showed no evidence of transmission.
examination and Western blot for PrPres confirmed TSE in both squirrel monkeys.
Epilepsy, psychosis, and schizophrenia: clinical and neuropathologic
For several years researchers have focused on A[[beta].sub.42] in cerebrospinal fluid (CSF) as a possible biomarker of Alzheimer's disease: Higher levels indicate the protein is still soluble, whereas lower levels suggest that it might be building up in the brain as neuropathologic
For several years researchers have focused on A[[beta].sub.42] in cerebrospinal fluid (CSF) as a possible biomarker of Alzheimer's disease (AD): Higher levels indicate the protein is still soluble, whereas lower levels suggest that it might be building up in the brain as neuropathologic
In a new study, therefore, the association of statin use and the specific neuropathologic
outcomes associated with Alzheimer disease (AD)--neurofibrillary tangles and neuritic plaques--were evaluated in patients who underwent brain autopsy.
subtypes of AD have been described, depending principally on the cortical regions most affected by neuronal loss, and the rates of disease progression may vary among them (4).
During 1996-2003, cases of CJD were identified in Japan by using 1) a mail survey of neurologic, psychiatric, and neuropathologic
institutions (overall response rate: 74%) (I) and 2) subsequent reporting of CJD patients by clinicians to MHW.
These findings amply support a neuropathologic
diagnosis of cerebral congophilic (amyloid) angiopathy.
Consistent with the inability of IHC or high sensitivity immunoblotting to detect pathologic PrP in the brains of inoculated mice, neuropathologic
examination of the brain showed no difference in spongiform change or gliosis from that observed in the brains of age-matched control mice (data not shown).