Because INKV induced limited disease in adult mice, we inoculated weanling mice intranasally with INKV to determine if neuropathogenicity was age dependent.
Overall, LACV showed the highest neuropathogenicity and neurovirulence in vitro and in vivo, whereas INKV was the least pathogenic.
A point mutation in a herpesvirus polymerase determines neuropathogenicity
. Plos pathogens.
The interactions between free radical induced oxidative stress, defects in mitochondrial energy metabolism, and excitotoxicity have widely been implicated in the neuropathogenicity
of avian influenza A virus by passages through air sac and brain of chicks.
(Stedman) 1 3 8 9 10 13 30 31 39 80 81 89 90 98
VDPVs show increased nucleotide divergence in the viral protein 1 (VP1) coding region in all variants of OPV serotypes (PV1, PV2, and PV3); this divergence is associated with increased neuropathogenicity
Revertant vaccine viruses with increased neuropathogenicity
might cause vaccine-associated paralytic poliomyelitis (VAPP) in OPV recipients or unimmunized contacts.
with experimental infection of equine herpesvirus 9 in common marmosets (Callithrixjacchus).
TMEV comprises strains of differing neuropathogenicity
, which constitute accepted mouse models of either human acute poliomyelitis or disseminated encephalomyelitis.
New insights on the neuropathogenicity
of West Nile virus.
Polylactosaminoglycan chains on the ectodomain of the primary envelope glycoprotein of an arterivirus determine its neuropathogenicity
, sensitivity to antibody neutralization and immunogenicity of the neutralization epitope.