neuropathic pain


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neuropathic pain

pain that results from direct stimulation of the myelin or nervous tissue of the peripheral or central nervous system (except for sensitized C fibers), generally felt as burning or tingling and often occurring in an area of sensory loss. It is seen commonly in patients with uncontrolled diabetes.

neuropathic pain

Pain that originates in peripheral nerves or the central nervous system rather than in other damaged organs or tissues. A hallmark of neuropathic pain is its localization to specific dermatomes or nerve distributions. Some examples of neuropathic pain are the pain of shingles (herpes zoster), diabetic neuropathy, radiculopathy, and phantom limb pain.

Treatment

Drugs like gabapentin or pregabalin provide effective relief of neuropathic pain for some patients. Other treatments include (but are not limited to) regional nerve blocks, selective serotonin and norepinephrine reuptake inhibitors, psychological counseling, acupuncture, transcutaneous electrical nerve stimulation, and physical therapy.

See also: pain

neuropathic pain

constant or spasmodic pain (e.g. shooting, burning, electrical, irritant, compressive, paraesthetic or scalding pain); pain occurs spontaneously or in response to non-noxious stimuli (allodynia); characteristic of nerve trauma, diabetic painful peripheral neuropathy, complex regional pain syndrome, compression neuropathies, postherpetic neuralgia; symptoms are managed by antidepressants, antiepileptic drugs (e.g. gabapentin), nerve blocks, transcutaneous electrical nerve stimulation (TENS); patients may require referral to multidisciplinary pain clinics
References in periodicals archive ?
Neuropathic pain is a common and complex pain condition caused by damage or diseases of the sensory nerves.
The capsaicin 8% patch delivers a high-dose of a synthetic form of capsaicin directly to the damaged pain sensing nerves in the skin that are the source of neuropathic pain.
The activation of NMDA receptors has been associated with neuropathic pain and it is expected that REL-1017 will have a role in pain management by blocking this activity.
8) conducted a before-and-after trial of SCI patients with pain, in which they found that gabapentin was effective in decreasing neuropathic pain refractory to conventional analgesics.
If the TPM/Oxycodone patch is shown to effectively reduce pain caused by PHN, it is very likely to be effective in treating many other neuropathic pain conditions, especially those where topical treatment could provide a therapeutic advantage (e.
Neuropathic pain is associated with changes in the transmission of signals between neurons, a process that depends on several types of voltage-gated calcium channels (VGCCs).
A review of the Diabetic Neuropathic Pain products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
The results suggested significant reductions in neuropathic pain in rats assigned to swimming or treadmill running.
Peripheral neuropathic pain is often described as burning, tingling, electrical, or stabbing by pins and needles.
Rates of neuropathic pain were highest in patients with a diagnosis of disc prolapse (65.
The diagnosis of neuropathic pain is a clinical one that is "based on a characteristic symptom profile that includes spontaneous sensations such as burning pain, numbness, and tingling, and evoked sensations such as sensitivity to light touch," she said.