neuropathic pain


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neuropathic pain

pain that results from direct stimulation of the myelin or nervous tissue of the peripheral or central nervous system (except for sensitized C fibers), generally felt as burning or tingling and often occurring in an area of sensory loss. It is seen commonly in patients with uncontrolled diabetes.

neuropathic pain

Pain that originates in peripheral nerves or the central nervous system rather than in other damaged organs or tissues. A hallmark of neuropathic pain is its localization to specific dermatomes or nerve distributions. Some examples of neuropathic pain are the pain of shingles (herpes zoster), diabetic neuropathy, radiculopathy, and phantom limb pain.

Treatment

Drugs like gabapentin or pregabalin provide effective relief of neuropathic pain for some patients. Other treatments include (but are not limited to) regional nerve blocks, selective serotonin and norepinephrine reuptake inhibitors, psychological counseling, acupuncture, transcutaneous electrical nerve stimulation, and physical therapy.

See also: pain

neuropathic pain

constant or spasmodic pain (e.g. shooting, burning, electrical, irritant, compressive, paraesthetic or scalding pain); pain occurs spontaneously or in response to non-noxious stimuli (allodynia); characteristic of nerve trauma, diabetic painful peripheral neuropathy, complex regional pain syndrome, compression neuropathies, postherpetic neuralgia; symptoms are managed by antidepressants, antiepileptic drugs (e.g. gabapentin), nerve blocks, transcutaneous electrical nerve stimulation (TENS); patients may require referral to multidisciplinary pain clinics
References in periodicals archive ?
Treatment is based on addressing the underlying conditions and managing neuropathic pain symptoms through a variety of methods and therapies, including physiotherapy and rehabilitation that help to maintain activities of daily living.
In conjunction, the ACCURATE study has demonstrated that DRG therapy can provide superior pain relief in patients with complex regional pain syndrome (CRPS) and other focal chronic neuropathic pain conditions compared to traditional spinal cord stimulation therapy, concluded the company.
The report reviews key players involved Diabetic Neuropathic Pain therapeutics and enlists all their major and minor projects
Mechanisms that modify the nervous system and contribute to neuropathic pain include abnormal nerve redevelopment, nerve sensitization, alterations in ion expression, loss of inhibition in modulating systems, and decreased availability of p-opioid peptide (MOP) receptors (Rodriguez, 2015).
Our study suggested that najanalgesin has a significant antinociceptive effect in a neuropathic pain model in rats.
According to PainDETECT, the prevalence of neuropathic pain was 44% in OA, 28% in AS, 18% in RA patients, and 8% in controls.
Taken as a whole, neuropathic pain is related to the injury or disorders affecting peripheral and central nervous systems,[14] and it is a symptom of heterologous conditions possessing different etiology and location.
In chronic phase, neuropathic pain predominates which results from the abnormal processing of sensory input due to damage to the nervous system2.
Additionally, CNV1014802 has demonstrated proof of concept for treating pain associated with lumbosacral radiculopathy, or sciatica, and has potential in other neuropathic pain.
It also reviews key players involved in the therapeutic development for Peripheral Neuropathic Pain and special features on late-stage and discontinued projects.