neuronal hyperplasia

neu·ro·nal hy·per·pla·si·a

increased numbers of ganglion cells with myenteric plexus hyperplasia and increased acetylcholinesterase activity in nerves of the mucosa and submucosa. Clinically, neuronal hyperplasia mimics Hirschsprung disease. Similar findings are seen in patients with multiple endocrine neoplasia syndrome, type IIB, and in neurofibromatosis.
References in periodicals archive ?
Kobayashi et al (46) speculate that inflammation, as opposed to distension alone, may be required to induce submucosal neuronal hyperplasia. Response to injury could also explain the IND-like hyperplasia of submucosal ganglia observed in intestinal allografts (47) and fibrosing colonopathy.
Diagnostic criteria for neuronal intestinal dysplasia type B include primarily submucosal neuronal hyperplasia, measured as the identification of at least 20% giant ganglia with at least 8 perikarya each, in 25 analyzed nerve ganglia, and other supportive findings.

Full browser ?