neuron-specific enolase


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neuron-specific enolase

an isoenzyme of enolase present in neurons and glial cells; stains for this enzyme are frequently used in the differential diagnosis of neuronal or neuroendocrine tumors.

neu·ron-spe·cif·ic e·no·lase

(nūr'on-spĕ-sif'ik ē'nō-lās)
An isoenzyme of enolase present in neurons and glial cells; stains for this enzyme are frequently used in the differential diagnosis of neuronal or neuroendocrine tumors.
References in periodicals archive ?
van Engelen, "Protein S-100B, neuron-specific enolase (NSE), myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and blood of neurological patients," Brain Research Bulletin, vol.
In this present study, TRF and [alpha]-TCP were administered at 100, 200, and 300 ng/mL to determine the ability of these isomers to scavenge ROS and modulate the expression of glutamate receptors and neuron-specific enolase, a marker of neuronal injury.
Serum neuron-specific enolase: a marker for disease extent and response to therapy of small-cell lung cancer.
(15,16) The positive reaction for neuron-specific enolase and SI00 both confirmed the neuronal origin of the tumor cells.
The consulting psychiatrist discussed this slowing, in conjunction with the abnormal MRI and elevated CSF neuron-specific enolase, with members of the referring Neurology service, who ordered additional testing of CSF for protein 14-3-3.
Due to their granular cytoplasm and strong expression of neuron-specific enolase and S-100, granular cell tumors are believed to originate from a neural source such as Schwann cells.
Chromogranin A (CgA), Pro-gastrin-releasing peptide (ProGRP), Neuron-specific enolase (NSE), Synaptophysin and Leu 7 are known as immunohistochemical tissue markers selective or closely associated with NE differentiation in various carcinomas (19).
Synaptophysin, chromogranin A and neuron-specific enolase as tumor markers in neuroendocrine tumors of the gastrointestinal tract and lung.
Objective: The effects of cardiopulmonary bypass (CPB) on serum neuron-specific enolase (NSE) levels in patients without cognitive dysfunction and neurological deficit are not yet clarified.
Specimens of ES may mark for S100 protein and neuron-specific enolase. (9) The immunohistochemical features of the presented cases correspond well to those of conventional ES.
Immunoperoxidase staining for neuron-specific enolase (NSE) was positive.
In 1983, Paul Zeltzer of the University of Texas Health Science Center at San Antonio and his colleagues found that children with neuroblastoma, a nerve cell cancer, had high levels of an enzyme called NSE (neuron-specific enolase) in the tumor and bloodstream.

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