neuromyelitis optica


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neuromyelitis

 [noor″o-mi″ĕ-li´tis]
inflammation of nervous and medullary substance; myelitis attended with neuritis.
neuromyelitis op´tica combined demyelination of the optic nerve and spinal cord, with diminution of vision and possible blindness, flaccid paralysis of extremities, and sensory and genitourinary disturbances.

neu·ro·my·e·li·tis op·'ti·ca

a demyelinating disorder consisting of a transverse myelopathy and optic neuritis.
Synonym(s): Devic disease

neu·ro·my·e·li·tis op·ti·ca

(nūr'ō-mī-ĕ-lī'tis op'tik-ă)
A demyelinating disorder consisting of a transverse myelopathy and optic neuritis.
Synonym(s): Devic disease.

neuromyelitis optica

An acute nervous system disorder featuring DEMYELINATION of the tracts in the nerve tracts in the spinal cord and both optic nerves. The condition occurs about a week after an attack of measles or chickenpox or may follow vaccination. There is headache, vomiting, stiff neck, paralysis and blindness and the death rate is high. In those who survive, recovery is often surprisingly complete. Also known as Devic's disease. (Eugene Devic, 1858–1930, French physician).

Devic,

Eugène, French physician, 1869-1930.
Devic disease - a demyelinating disorder consisting of a transverse myelopathy and optic neuritis. Synonym(s): neuromyelitis optica
References in periodicals archive ?
Neuromyelitis optica spectrum disorders and non-organ-specific autoimmunity.
Impact of eculizumab on disability measures in patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder: phase 3 PREVENT study.
Neuromyelitis optica: a positive appraisal of seronegative cases.
Other monophasic subtypes include monophasic neuromyelitis optica spectrum diseases (NMOSDs) accompanied by optic neuritis and/or transverse myelitis [9, 12, 17, 18], as well as clinically isolated syndromes [optic neuritis (ON), transverse myelitis (TM), cerebellitis, and brainstem disease], which present after puberty and do not confer risk factors for further MS-like episodes, such as positive oligoclonal bands (OCBs) or MS-like lesions on MRI [9, 10, 12, 16].
Neuromyelitis optica (NMO), or Devic's disease, is a rare autoinflammatory demyelinating disease of the optic nerves and spinal cord, characterized by optic neuritis and longitudinally extensive transverse myelitis [1,2].
showed that four polymorphisms (rs7528684, rs945635, rs3761959, and rs2282284) in FCRL3 gene can increase the risk for neuromyelitis optica (NMO) [34].
Neuromyelitis optica (NMO) is an autoimmune inflammatory disease that selectively targets the optic nerves and spinal cord, leading to blindness and paralysis [1].
Neuromyelitis optica (NMO), also known as Devic's disease, is a central nervous system (CNS) autoimmune disease that preferentially affects the spinal cord and optic nerve [1].
Neuromyelitis optica spectrum disorder (NMOSD) is a chronic autoimmune demyelinating disease of the CNS, usually of the optic nerve and spinal cord, that is associated with serum anti-aquaporin-4 (AQP4) immunoglobulin G antibodies, which have a sensitivity of 60~70% and specificity of 99% for the disease.
Test results were negative for autoantibodies (antinuclear antibodies; c and p antineutrophil cytoplasmic antibodies; double-stranded DNA antibodies; and antiphospholipid, onconeural, and neuromyelitis optica [antiaquaporin 4] autoantibodies).