neuromuscular transmission

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Related to neuromuscular transmission: neuromuscular junction

neuromuscular transmission

the mechanism whereby motor nerve impulses initiate muscle contraction. When the impulses reach the motor nerve terminal (end plate), they cause vesicles containing acetylcholine to be released, which traverse the synaptic cleft and, on reaching the postsynaptic membrane, generate muscle action potentials.


pertaining to nerve terminations in muscles.

neuromuscular blockade
deliberate paralysis of the motor end-plates; important in veterinary surgery for immobilization. It is effected by the use of competitive (non-depolarizing) agents such as d-tubocurarine, and depolarizing agents such as succinylcholine.
neuromuscular blocking agents
drugs capable of producing neuromuscular blockade (above).
neuromuscular junction
the point of junction of a nerve fiber with the muscle that it innervates. It includes an area of folded sarcolemma of the muscle fiber, and an axon terminal located in the folds and containing vesicles of the neurotransmitter acetylcholine. Called also myoneural junction.
neuromuscular junction disease
examples are tick paralysis, botulism, myasthenia gravis.
neuromuscular paralysis
paralysis caused by malfunction at the neuromuscular junction, e.g. after administration of a neuromuscular blocking agent. The paralysis may be flaccid or spastic.
phase-II neuromuscular block
alteration of the end-plate threshold to depolarization by acetylcholine following prolonged use of a depolarization agent such as succinylcholine.
neuromuscular spindle
consists of muscle fiber, afferent and efferent nerve endings and connective tissue; maintains muscle tone via stretch reflex mediated through two neurons at spinal cord level.
neuromuscular transmission
release of acetylcholine from the nerve ending and activation of the receptors in the muscle end-plate.
References in periodicals archive ?
They enrolled 52 patients of American Society of Anesthesiologists physical status I or II undergoing elective lower abdominal or mastectomy procedures; no patient with neuromuscular disease or taking medications that might interfere with neuromuscular transmission was included in the study.
After induction of general anaesthesia, the supramaximal stimulation current was established using the automatic function of the Neuromuscular Transmission Monitor-EMG before the administration of any NMB.
Neuromuscular transmission was monitored using the TOF-Watch[R] SX (Organon Teknika, Boxtel, The Netherlands) (5,6).
The device is a neuromuscular transmission monitor capable of estimating the degree of neuromuscular block in anesthetized patients.
Objective (quantitative) neuromuscular transmission monitoring is the only means of adequately assessing RNMB (3,4).
Current parameters include EEG (also featuring Auditory Evoked Potential monitoring), neuromuscular transmission (NMT) for monitoring of neuromuscular blockade as well as electromyogram (EMG) and electrocardiogram (ECG) derivatives for monitoring of analgesia.
Perioperative monitoring of neuromuscular transmission using acceleromyography prevents residual neuromuscular block following pancuronium.
The correlation between depression of neuromuscular transmission and serum magnesium concentration has been established to be safe at a therapeutic range of 2 to 4 mmol/l in eclampsia (10,11) and this has been extrapolated to tetanus.