neuromuscular transmission


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Related to neuromuscular transmission: neuromuscular junction

neuromuscular transmission

the mechanism whereby motor nerve impulses initiate muscle contraction. When the impulses reach the motor nerve terminal (end plate), they cause vesicles containing acetylcholine to be released, which traverse the synaptic cleft and, on reaching the postsynaptic membrane, generate muscle action potentials.
References in periodicals archive ?
The effects of small incremental doses of d-tubocurarine on neuromuscular transmission in anesthetized man.
SCS, usually an autosomal dominant disorder of postsynaptic CMS, is caused by a kinetic abnormality of the AChR which comprises the healthy safety margin of neuromuscular transmission. SCS is characterized by the slow decay of endplate currents (Figure 2), destabilization of the closed channel state, prolonged activation episodes of AChR, and an endplate myopathy caused by cationic overloading of the muscle fibers.
PACU length of stay was significantly longer in patients with T4/T1<0.9(323min), compared with patients with adequate recovery of neuromuscular transmission (243min).
Availability, types and preferences of neuromuscular transmission monitors
The Datex-Ohmeda GE Healthcare Neuromuscular Transmission Monitor-EMG (Helsinki, Finland) allows automatic detection of supramaximal stimulation with minimal set-up time, monitoring of many sites, and gives a graphical and numerical display of twitch height and TOF.
As serotonin can indirectly potentiate cholinergic neuromuscular transmission in isolated human detrusor muscle strips (10) and there are a number of case reports on SSRI-induced enuresis (11-14), aripiprazole may be responsible for enuresis because of its serotonin reuptake properties (SERT).
In the second condition (local anesthesia), 10 fish were injected with pancuronium bromide (0.1 mg/kg; Sigma) to block neuromuscular transmission and were then placed in an operating chamber, where a respiratory current of chilled seawater was applied through the mouth and over the gills.
Myasthenia gravis (MG) is characterized by muscular fatigue due to a defect in neuromuscular transmission. [sup][1] In ocular myasthenia gravis (OMG), weakness is limited to the extrinsic ocular muscles, and no facial muscles or extremity muscles are involved.
Excessive copper may interfere with neuromuscular transmission. (10) Decreased pseudocholinesterase levels slow the metabolism of succinyl choline.
Neuromuscular transmission: new concepts and agents.
Ptosis, diplopia and blurred vision were common finding Neuromuscular paralysis occurs as a result of blockade of neuromuscular transmission. The neurotoxins have phospholipase A2 activity and hydrolyze phosphoglycerides thereby producing neuromuscular blockade by inhibiting the release of acetylcholine from the presynaptic membrane.