neuromuscular relaxant


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neu·ro·mus·cu·lar re·lax·ant

an agent (for example, curare or succinylcholine) that produces relaxation of striated muscle by interruption of transmission of nervous impulses at the myoneural junction.

neuromuscular relaxant

A drug (e.g., succinylcholine) that prevents transmission of stimuli to muscle tissue, esp. striated muscle.
See also: relaxant
References in periodicals archive ?
Presynaptic facilitatory adenosine [A.sub.2A] receptors mediate fade induced by neuromuscular relaxants that exhibit anticholinesterase activity.
Presynaptic muscarinic and adenosine receptors involved in 2Hz-induced train-of-four fade caused by antinicotinic neuromuscular relaxants in the rat.
Based on the above statements and considering the major impact of evaluating both the incidence and current management of Rp in patients over 65 years old, we tried to respond the following question: "What is the incidence of Rp in patients over 65 years of age, exposed to nondepolarizing neuromuscular relaxants? Which are the characteristics of the current treatment for residual paralysis in patients aged 65 and older?
The cohort inclusion criteria included: patients over 65 years old exposed to nondepolarizing neuromuscular relaxants. All patients discharged from the ICU with mechanical ventilation were excluded.
The data recorded included demographics (age, gender, body weight, height), pre-surgical information (comorbidities, use of pre-anesthesia drugs, surgical diagnosis, and intraoperative variables such as IV anesthetic agents, inhaled anesthesia, antibiotics, GI protective agents, antiemetics, and divalent electrolytes, in addition to the neuromuscular relaxants studied at full and body weight estimated doses).
An important consideration is that in our setting, despite the frequent use of nondepolarizing neuromuscular relaxants, a protocol is not followed and exclusively depends on the anesthetist's skill.
Among the nondepolarizing neuromuscular relaxants, rocuronium is the agent of choice due to its short half-life, but always under neuromuscular relaxation monitoring.

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