neuromuscular blocking agent


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neu·ro·mus·cu·lar block·ing a·gent

(nūr'ō-mŭs'kyū-lăr blok'ing ā'jĕnt)
A drug used to block neuromuscular transmission at the myoneural junction, which elicits paralysis of the affected skeletal muscles. This type of drug may also cause hypotension, flushing, tachycardia, and bronchospasms and should be used with caution in those with myasthenia gravis, in old and debilitated patients, and in those with renal, hepatic, and pulmonary disease.

neuromuscular blocking agent

Any of a class of drugs that causes muscle paralysis by blocking the transmission of nerve stimuli to muscles. They are esp. useful as an adjunct to anesthesia to induce skeletal muscle relaxation, to facilitate the management of patients undergoing mechanical ventilation, and to facilitate tracheal intubation. They are also used to treat status epilepticus and to reduce metabolic demands by preventing shivering or muscle rigidity.

CAUTION!

These drugs may cause respiratory depression and should be administered only by persons who regularly manage respiratory failure with artificial ventilation.
See also: neuromuscular
References in periodicals archive ?
Neuromuscular blocking agents had never been available as floor stock in the nursery.
Use of sedatives, opioids, and neuromuscular blocking agents in patients with acute lung injury and acute respiratory distress syndrome.
Among the neuromuscular blocking agents, suxamethonium may be the fastest drug over onset time, as one kind of depolarization muscular
Neuromuscular blocking agents are commonly utilized as adjuvants to general anesthetics to facilitate ventilation, and in thoracic, orthopedic and intraocular surgeries, in this case to produce centralization of the eyeball (GLOVER & CONSTANTINESCU, 1997), keeping the cornea totally visible and thereby facilitating surgical procedures.
--Excerpt from Florida's recently-revised execution protocol (131) [C]urare, curariform mixtures, [or] any substance which acts as a neuromuscular blocking agent ...
Cebo's action was compared to the well-known effects of the cholinesterase inhibitor neostigmine in the presence of the neuromuscular blocking agent gallamine.
The second, pancuronium bromide, a neuromuscular blocking agent used to relax muscles of head injury and heart attack victims, stops the breathing.
US: ultrasound; NMBA: neuromuscular blocking agent References in Appendix
Depolarizing neuromuscular blocking agent: So many depolarizing neuromuscular blocking agents have been synthesized but only succinyl choline stood the test of time.
Recently, good mydriasis without systemic adverse effects was obtained in nocturnal and diurnal birds of prey by using topically applied rocuronium bromide, a neuromuscular blocking agent and derivative of vecuronium bromide.
In addition, the company revealed its vecuronium bromide for injection is a neuromuscular blocking agent and is indicated in small doses for patients who have myasthenia gravis or the myasthenic (Eaton- Lambert) syndrome (muscle weakness/fatigue).
On one hand, we have now the feeling that we can use the neuromuscular blocking agents ("NMBA's") in a wider, safer margin.