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1. in pharmacology, the blocking of the effect of a neurotransmitter or hormone by a drug.
2. in histochemistry, a chemical reaction that modifies certain chemical groups and blocks a specific staining method.
adrenergic blockade selective inhibition of the response to sympathetic impulses transmitted by epinephrine or norepinephrine at alpha or beta receptor sites of an effector organ or postganglionic adrenergic neuron. See also adrenergic blocking agent.
cholinergic blockade selective inhibition of cholinergic nerve impulses at autonomic ganglionic synapses, postganglionic parasympathetic effectors, or neuromuscular junctions. See also cholinergic blocking agent.
ganglionic blockade inhibition by drugs of nerve impulse transmission at autonomic ganglionic synapses; see also ganglionic blocking agent.
narcotic blockade inhibition of the euphoric effects of narcotic drugs by the use of other drugs, such as methadone, in the treatment of addiction.
neuromuscular blockade a failure in neuromuscular transmission that can be induced pharmacologically or result from any of various disturbances at the myoneural junction. See also neuromuscular blocking agent.
sympathetic blockade block of nerve impulse transmission between a preganglionic sympathetic fiber and the ganglion cell.
neuromuscular blockadeNeurology The partial or complete inhibition of motor activity at a neuromuscular junction Etiology
1. Reduction of post-synaptic receptors–eg, myasthenia gravis;.
2. Defective acetylcholine release from storage vesicles–eg, botulism, myasthenia, or Eaton-Lambert syndrome;.
3. Competition for binding sites, either pharmacologic blockade–eg, neostigmine, edrophonium, or toxins–eg, organophosphate insecticides. See Neuromuscular junction.
neu·ro·mus·cu·lar block·ade(nūr'ō-mŭs'kyū-lăr blok-ād')
The blockage of transmission through the myoneural junction at nicotinic receptors, decreasing skeletal muscle tone and resulting in muscle weakness and/or paralysis.