neuromuscular blockade


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blockade

 [blok-ād´]
1. in pharmacology, the blocking of the effect of a neurotransmitter or hormone by a drug.
2. in histochemistry, a chemical reaction that modifies certain chemical groups and blocks a specific staining method.
adrenergic blockade selective inhibition of the response to sympathetic impulses transmitted by epinephrine or norepinephrine at alpha or beta receptor sites of an effector organ or postganglionic adrenergic neuron. See also adrenergic blocking agent.
cholinergic blockade selective inhibition of cholinergic nerve impulses at autonomic ganglionic synapses, postganglionic parasympathetic effectors, or neuromuscular junctions. See also cholinergic blocking agent.
ganglionic blockade inhibition by drugs of nerve impulse transmission at autonomic ganglionic synapses; see also ganglionic blocking agent.
narcotic blockade inhibition of the euphoric effects of narcotic drugs by the use of other drugs, such as methadone, in the treatment of addiction.
neuromuscular blockade a failure in neuromuscular transmission that can be induced pharmacologically or result from any of various disturbances at the myoneural junction. See also neuromuscular blocking agent.
sympathetic blockade block of nerve impulse transmission between a preganglionic sympathetic fiber and the ganglion cell.

neuromuscular blockade

Neurology The partial or complete inhibition of motor activity at a neuromuscular junction Etiology
1. Reduction of post-synaptic receptors–eg, myasthenia gravis;.
2. Defective acetylcholine release from storage vesicles–eg, botulism, myasthenia, or Eaton-Lambert syndrome;.
3. Competition for binding sites, either pharmacologic blockade–eg, neostigmine, edrophonium, or toxins–eg, organophosphate insecticides. See Neuromuscular junction.

neu·ro·mus·cu·lar block·ade

(nūr'ō-mŭs'kyū-lăr blok-ād')
The blockage of transmission through the myoneural junction at nicotinic receptors, decreasing skeletal muscle tone and resulting in muscle weakness and/or paralysis.
References in periodicals archive ?
Neuromuscular blockade and skeletal muscle weakness in critically ill patients: Time to rethink the evidence?
A total of 150 patients fulfilling the inclusion/exclusion criteria were enrolled to compare the mean duration of atracurium-induced neuromuscular blockade in minutes when dosed according to real body weight (RBW) or ideal body weight (IBW) to obese patients selected for abdominal surgeries under GA.
Sugammadex provides faster reversal of vecuronium-induced neuromuscular blockade compared with neostigmine: a multicenter, randomized, controlled trial.
Neuromuscular blockade can be used to reduce myogenic artifact allowing for clearer visualization of the underlying cerebral activity as we have demonstrated.
Lee et al., "The combination of sugammadex and neostigmine can reduce the dosage of sugammadex during recovery from the moderate neuromuscular blockade," Korean Journal of Anesthesiology, vol.
(15,16) In our study, 84% of non-survivors received continuous neuromuscular blockade, suggesting a positive dose-dependent association with mortality.
Because succinylcholine produces rapid, intense neuromuscular blockade, many physicians still believe that it is the drug of choice for RSI.
Saldien et al., "A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia," Anesthesia and Analgesia, vol.
However, concomitant use of a calcium-channel blocker and magnesium sulfate can sometimes lead to neuromuscular blockade and significant respiratory depression, even necessitating mechanical ventilation.
However it was not until 1949 that reports emerged outlining assessment of the degree of neuromuscular blockade.