Neuromedin U receptor 2 | definition of neuromedin U receptor 2 by Medical dictionary
NMUR2 (redirected from neuromedin U receptor 2)
NMUR2 A gene on chromosome 5q33.1 that encodes a neuromedin U (NMU) receptor of the Gq/11-protein-coupled receptor family, which is expressed in the CNS—especially in the substantia nigra, medulla oblongata and pontine reticular formation. NMU receptors mediate various biological effects, including uterine contraction, vasoconstriction and activation of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in decreased food intake via the corticotropin releasing hormone (CRH) system.
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References in periodicals archive
The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2).
Neuromedin U receptor 2 knockdown in the paraventricular nucleus modifies behavioral responses to obesogenic high-fatfood and leads to increased body weight.
Biopharmaceutical company Omeros Corporation (NASDAQ:OMER) reported on Tuesday the receipt of a grant, valued at USD1.04m, from the National Institute on Drug Abuse (NIDA) to fund further drug development against neuromedin U receptor 2