Neurolymphomatosis (NL) is a rare condition of lymphomatous infiltration of peripheral nervous system, usually by B-cell non-Hodgkin lymphoma (NHL).
Negative sural nerve biopsy in neurolymphomatosis. J Neurol.
Neurolymphomatosis: diagnosis, management, and outcomes in patients treated with rituximab.
To the Editor: Neurolymphomatosis (NL) is a clinical disorder that presents with peripheral neuropathy due to lymphomatous infiltration of the nerves.
Neurolymphomatosis: An international primary CNS lymphoma collaborative group report.
All were due to Non-Hodgkin's lymphoma out of which 3 were due to neurolymphomatosis and 3 were due to leptomeningeal involvement.
Neurolymphomatosis (NL)(16) seen in three of our patients is characterized by infiltration of malignant lymphocytes into the peripheral nervous system particularly the cranial nerves, spinal nerve roots, brachial/lumbar plexus, and/or peripheral nerves.
For the suspected case of neurolymphomatosis, patient 8, a dual color probe for the 3q27 (BCL6) locus was used for enumeration of chromosome 3 and a dual color MALT1 (18q21) break apart probe for that locus to assess translocation.
This case was suspected to be neurolymphomatosis by light microscopy (Figure 1, I) and the combination of immunoreactivity for both CD5 (Figure 1, J) and bcl-2, but all attempts to prove clonality by polymerase chain reaction-based gene rearrangement were negative.