(108,109) Using optogenetic neurostimulation, neuroligin-3 was identified as a secreted synaptic protein that drives the PI3K-mTOR pathway in xenografted high-grade glioma.
Neuronal activity promotes glioma growth through neuroligin-3 secretion.
(2007) A neuroligin-3
mutation implicated in autism increases inhibitory synaptic transmission in mice.
Johung, V Caretti et al., "Neuronal activity promotes glioma growth through neuroligin-3
secretion," Cell, vol.
An international team, led by researchers at the University of California, found that misfolding of a protein called neuroligin-3
, due to gene mutations, results in trafficking deficiencies that may lead to abnormal communications between neurons.
Sharma et al., "Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function," Proceedings of the National Academy of Sciences of the United States of America, vol.
Scheiffele, "Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses," European Journal of Neuroscience, vol.
Further investigation into the overlapping neural substrates underlying mating and aggressive behavior in the [NL3.sup.R451C] mouse may shed light into the role of Neuroligin-3 in mediating complex social behavior in mice.
NL3: Neuroligin-3 R451C: Arginine to cysteine residue 451 substitution WT: Wild-type.