NLGN3

(redirected from neuroligin-3)

NLGN3

A gene on chromosome Xq13.1 that encodes neuroligin 3, a neuronal cell surface protein involved in cell–cell interactions, which forms intercellular junctions by binding to beta-neurexins. It may play role in forming or maintaining synaptic junctions, as well as glia–glia or glia–neuron interactions in the developing peripheral nervous system.
 
Molecular pathology
Defects of NLGN3 have been linked to an increased susceptibility to Asperger syndrome (X-linked type 1) and to autism (X-linked type 1).
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References in periodicals archive ?
(108,109) Using optogenetic neurostimulation, neuroligin-3 was identified as a secreted synaptic protein that drives the PI3K-mTOR pathway in xenografted high-grade glioma.
Neuronal activity promotes glioma growth through neuroligin-3 secretion.
(2007) A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Johung, V Caretti et al., "Neuronal activity promotes glioma growth through neuroligin-3 secretion," Cell, vol.
An international team, led by researchers at the University of California, found that misfolding of a protein called neuroligin-3, due to gene mutations, results in trafficking deficiencies that may lead to abnormal communications between neurons.
Sharma et al., "Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function," Proceedings of the National Academy of Sciences of the United States of America, vol.
Scheiffele, "Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses," European Journal of Neuroscience, vol.
Further investigation into the overlapping neural substrates underlying mating and aggressive behavior in the [NL3.sup.R451C] mouse may shed light into the role of Neuroligin-3 in mediating complex social behavior in mice.
NL3: Neuroligin-3 R451C: Arginine to cysteine residue 451 substitution WT: Wild-type.