We summarize studies of knockout (KO) mice shedding light on the role of three proteins (neuroligin-1, neuroligin-2, and collybistin) involved in the regulation of glutamatergic and GABAergic transmission (Figure 1).
Neuroligin-2 Regulates Perisomatic Inhibitory Synaptic Transmission in the Dentate Gyrus
Neuroligin-2 (NL2) is a postsynaptic adhesion protein which is present at inhibitory synapses .
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Neuroligin-1 is a specific CAM for excitatory (glutamatergic) synapses, while neuroligin-2
is a specific CAM for inhibitory (GABAergic) synapses.
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Kraev et al., "Impaired hippocampal neuroligin-2
function by chronic stress or synthetic peptide treatment is linked to social deficits and increased aggression," Neuropsychopharmacology, vol.