NLGN2

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NLGN2

A gene on chromosome 17p13.1 that encodes neuroligin 2, a neuronal cell surface protein involved in cell–cell interactions (e.g., in neurons and in other types of cells, such as Langerhans beta cells), which forms intercellular junctions by binding to beta-neurexins. It may play role in forming or maintaining synaptic junctions.
References in periodicals archive ?
We summarize studies of knockout (KO) mice shedding light on the role of three proteins (neuroligin-1, neuroligin-2, and collybistin) involved in the regulation of glutamatergic and GABAergic transmission (Figure 1).
Neuroligin-2 Regulates Perisomatic Inhibitory Synaptic Transmission in the Dentate Gyrus
Neuroligin-2 (NL2) is a postsynaptic adhesion protein which is present at inhibitory synapses [58].
Etherton et al., "Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2," Neuron, vol.
Sudhof, "Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatinpositive interneurons," The Journal of Neuroscience, vol.
Wang et al., "The down-regulation of neuroligin-2 and the correlative clinical significance of serum GABA over-expression in Hirschsprung's disease," Neurochemical Research, vol.
Neuroligin-1 is a specific CAM for excitatory (glutamatergic) synapses, while neuroligin-2 is a specific CAM for inhibitory (GABAergic) synapses.
Qin et al., "Identification and functional characterization of rare mutations of the neuroligin-2 gene (NLGN2) associated with schizophrenia," Human Molecular Genetics, vol.
Grosse et al., "Hippocampal neuroligin-2 overexpression leads to reduced aggression and inhibited novelty reactivity in rats," PLoS ONE, vol.
Kraev et al., "Impaired hippocampal neuroligin-2 function by chronic stress or synthetic peptide treatment is linked to social deficits and increased aggression," Neuropsychopharmacology, vol.