NLGN1

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NLGN1

A gene on chromosome 3q26.31 that encodes neuroligin 1, a neuronal cell surface protein involved in cell–cell interactions, which forms intercellular junctions by binding to beta-neurexins. NLLGN1 may play role in forming or maintaining synaptic junctions; it may be involved in specification of excitatory synapses.
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We summarize studies of knockout (KO) mice shedding light on the role of three proteins (neuroligin-1, neuroligin-2, and collybistin) involved in the regulation of glutamatergic and GABAergic transmission (Figure 1).
Neuroligin-1 Regulates Excitatory Synaptic Transmission and LTP in the Dentate Gyrus
Synaptic Plasticity and Excitation-Inhibition Balance in the Dentate Gyrus: Insights from In Vivo Recordings in Neuroligin-1, Neuroligin-2, and Collybistin Knockouts
Kwon et al., "Transsynaptic signaling by activity-dependent cleavage of neuroligin-1," Neuron, vol.
Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development
In this work, the abundance of neurexin II and neuroligin-1 in the ENS of rats at different embryonic days was investigated through quantitative real-time PCR, western blot, and immunofluorescence staining.
Then, Ct of neuroligin-1, neurexin II, and [beta]-actin was measured to calculate [DELTA]Ct (Ct of neuroligin-1 or neurexin II minus Ct of [beta]-actin).
Abundance and Significance of Neuroligin-1 and Neurexin II in the Enteric Nervous System of Embryonic Rats
The protein - Neuroligin-1 (NLGN1) - is known to be involved in memory formation; this is the first time it's been linked to amyloid-associated memory loss.
Mechanism behind Alzheimer's-related memory loss identified
Neuroligin-1 is a specific CAM for excitatory (glutamatergic) synapses, while neuroligin-2 is a specific CAM for inhibitory (GABAergic) synapses.
Dissipationless waves for information transfer in neurobiology--some implications
Nakahara et al., "Activity-dependent proteolytic cleavage of neuroligin-1, " Neuron, vol.
Meriney, "Distinct roles of neuroligin-1 and SynCAM1 in synapse formation and function in primary hippocampal neuronal cultures," Neuroscience, vol.
Dynamic Control of Synaptic Adhesion and Organizing Molecules in Synaptic Plasticity
Lee et al., "Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals," Proceedings of the National Academy of Sciences, vol.
Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders
Kwon et al., "Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors," Proceedings of the National Academy of Sciences of the United States of America, vol.
Astrocyte-synapse structural plasticity
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