NLGN1

(redirected from neuroligin-1)

NLGN1

A gene on chromosome 3q26.31 that encodes neuroligin 1, a neuronal cell surface protein involved in cell–cell interactions, which forms intercellular junctions by binding to beta-neurexins. NLLGN1 may play role in forming or maintaining synaptic junctions; it may be involved in specification of excitatory synapses.
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The protein - Neuroligin-1 (NLGN1) - is known to be involved in memory formation; this is the first time it's been linked to amyloid-associated memory loss.
Mechanism behind Alzheimer's-related memory loss identified
Neuroligin-1 is a specific CAM for excitatory (glutamatergic) synapses, while neuroligin-2 is a specific CAM for inhibitory (GABAergic) synapses.
Dissipationless waves for information transfer in neurobiology--some implications
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