NLGN3

(redirected from neuroligin 3)

NLGN3

A gene on chromosome Xq13.1 that encodes neuroligin 3, a neuronal cell surface protein involved in cell–cell interactions, which forms intercellular junctions by binding to beta-neurexins. It may play role in forming or maintaining synaptic junctions, as well as glia–glia or glia–neuron interactions in the developing peripheral nervous system.
 
Molecular pathology
Defects of NLGN3 have been linked to an increased susceptibility to Asperger syndrome (X-linked type 1) and to autism (X-linked type 1).
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References in periodicals archive ?
Cell adhesion molecule Abbreviation Neural cell adhesion molecule NCAM Polysialated neural cell adhesion molecule PSA-NCAM Neuronal cell adhesion molecule NRCAM Immunoglobulin super family IGSF Synaptic cell adhesion molecule SYNCAM Intercellular adhesion molecule 5 ICAM5 Cadherin 13 CDH13 Neurexin 3 NRXN3 Neurexin 2[beta] NRXN2[beta] Neuroligin 3 NLGN3 Neuroligan 1 NLGN1 Neurexin 3[beta] NRXN3[beta] Protein tyrosine phosphatase receptor D PTPRD Protein tyrosine phosphatase receptor B PTPRB CUB and Sushi multiple domains 1 CSMD1 Protein tyrosine phosphatase receptor Z 1 PTPRZ1 Table 2: Gene expression changes after repeated cocaine treatment.
El gen IL13RA3 esta localizado en el cromosoma Xq13.1-q28, donde se han descrito ligamiento con LOD score mayor a 2 y alteraciones citogeneticas (60, 61); por lo que han sido postulados otros genes candidato como los genes de las neuroliguinas 3 y 4 (NLGN3 o Neuroligin 3) (25).
* NLGN 3: Neuroligin 3. Expresion en el sistema nervioso central del adulto y fetal terminales.
Currently, there is only very limited information available on the etiology and biological basis of the autism spectrum disorders, although a mutation in the neuroligin 3 gene has caught researchers' attention in recent studies.
The neuroligin 3 mutation, an arginine-to-cysteine substitution, was identified in a set of twins and has been shown to result in most of the expressed protein being retained within the endoplasmic reticulum.
Coutinho et al., "Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients," Molecular Psychiatry, vol.
Cherubini, "Developmental regulation of GABAergic signalling in the hippocampus of neuroligin 3 R451C knock-in mice: an animal model of Autism," Frontiers in Cellular Neuroscience, vol.
Neuroligin 3 is expressed by neurons but also by glial cells, in particular in the ensheathing glia in olfactory bulb as well as in retinal astrocytes [78].