NLGN2

(redirected from neuroligin 2)

NLGN2

A gene on chromosome 17p13.1 that encodes neuroligin 2, a neuronal cell surface protein involved in cell–cell interactions (e.g., in neurons and in other types of cells, such as Langerhans beta cells), which forms intercellular junctions by binding to beta-neurexins. It may play role in forming or maintaining synaptic junctions.
References in periodicals archive ?
Brose, "Neuroligin 2 is exclusively localized to inhibitory synapses," European Journal of Cell Biology, vol.
Meyer et al., "Neuroligin 2 deletion alters inhibitory synapse function and anxiety-associated neuronal activation in the amygdala," Neuropharmacology, vol.
Nam et al., "The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development," The Journal of Cell Biology, vol.
For example, some SAMs can bind partners tethered to the same membrane in a side-by-side fashion forming a "cis-complex." Such cis-protein assemblies are often regulatory in nature, altering, binding, or forming an essential precomplex onto which a third partner can dock to yield the final trans-synaptic bridge, for example, MDGA1 binding to neuroligin 2 (NLGN2) [16, 17], the CNTNAP2-CNTN2 tripartite system [18], and SALM4 binding to SALM3 which inhibits trans-synaptic SALM3-LAR adhesion [19].
Roca-Lapirot et al., "Unexpected association of the 'inhibitory' neuroligin 2 with excitatory PSD95 in neuropathic pain," Pain, vol.
Bolliger et al., "Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2," Genes, Brain and Behavior, vol.
This behavioral change in chronically restrained rats was attributed to a decrease in neuroligin 2 in the hippocampus [40].