NLGN1

(redirected from neuroligin 1)

NLGN1

A gene on chromosome 3q26.31 that encodes neuroligin 1, a neuronal cell surface protein involved in cell–cell interactions, which forms intercellular junctions by binding to beta-neurexins. NLLGN1 may play role in forming or maintaining synaptic junctions; it may be involved in specification of excitatory synapses.
References in periodicals archive ?
Nicoll, "A subtype-specific function for the extracellular domain of neuroligin 1 in hippocampal LTP," Neuron, vol.
After cleaving of neuroligin 1 by MMP-9 modification of synaptic transmission was observed.
Sudhof, "A splice code fortrans-synaptic cell adhesion mediated by binding of neuroligin 1 to [alpha]- and [beta]-neurexins," Neuron, vol.
This synaptogenic effect of TSP-1 is mediated by neuroligin 1, a membrane protein involved in the formation of CNS synapses [22].
Xia, "Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1," Nature Neuroscience, vol.
Binding receptors or Functions References molecules Antiangiogenic [13, 45-50] Proinflammatory [15, 51] CD36 Anti-inflammatory [17, 45] Proapoptotic [14] Profibrogenic [21, 52] Antiangiogenic [49] CD47 Anti-inflammatory [45] Proapoptotic [18,19] TNF-R1 Proapoptotic [20] TGF-[beta] Anti-inflammatory [53] Profibrogenic [54] MMP-9 Antiangiogenic [55, 56] [alpha]2[delta]-1, Prosynaptogenic [22, 24] neuroligin 1
Transcripts belonging to this category that are of particular interest include neurexins 1 and 3 (NRXN1 and NRXN3, resp.) and neuroligin 1 (NLGN1), whose mutations are found to associate with various neurological diseases, including autism spectrum disorders [56].
Pechmann et al., "Neuroligin 1 is dynamically exchanged at postsynaptic sites," Journal of Neuroscience, vol.
Sudhof, "A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to [alpha]- and [beta]-neurexins," Neuron, vol.
Brose, "Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses," Proceedings of the National Academy of Sciences of the United States of America, vol.
Naguib, "Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency," Nature Neuroscience, vol.
However, at glutamatergic synapses, neuroligin 1 binds to postsynaptic scaffolding protein PSD-95 that links to GKAP which in turn binds Shank, and this complex may further recruit other postsynaptic proteins to the excitatory synaptic junctions (read [81] for a review on neuroligins).