neuroleptic malignant syndrome


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Related to neuroleptic malignant syndrome: tardive dyskinesia, Serotonin syndrome

neuroleptic

 [noor″o-lep´tik]
a term coined to refer to the effects on cognition and behavior of the original antipsychotic agents, which produced a state of apathy, lack of initiative, and limited range of emotion and in psychotic patients caused a reduction in confusion and agitation and normalization of psychomotor activity. The term is still used to refer to agents, such as droperidol, used to produce such effects as part of anesthesia or analgesia; however, it is outdated as a synonym for antipsychotic agents because newer agents do not necessarily have such effects.
neuroleptic malignant syndrome a rare but dramatic condition that occurs in severely ill patients being treated with high-potency antipsychotics (neuroleptics); symptoms include diaphoresis, muscle rigidity, and hyperpyrexia. It is believed to be caused by dopamine blockade in the hypothalamus.

neu·ro·lep·tic ma·lig·nant syn·drome

hyperthermia with extrapyramidal and autonomic disturbances that may result in death, following the use of neuroleptic agents.

neuroleptic malignant syndrome

Neurology A disorder seen in those receiving antipsychotics–eg, haloperidol, major tranquilizers, and other agents–eg, phenothiazines, reserpine, butyrophenone, an effect attributed to dopamine blockade in the basal ganglia and hypothalamus; NMS may also be associated with anesthesia, affecting +– 1:50,000 Pts exposed to inhalation anesthesia, most commonly in young ♂, transiently weakened by exhaustion, dehydration Clinical Fever ≥ 41ºC, extrapyramidal Sx–eg, rigidity, involuntary movements, facial dyskinesia, skeletal muscle hypertonicity, loss of consciousness, autonomic lability–pallor, sweating, tachycardia, arrhythmia, transient HTN which, if severe, may cause renal failure Mortality 20-30%, often between days 3-30, usually from renal failure Treatment Bromocriptine or dantrolene may shorten clinical disease.

neu·ro·lep·tic ma·lig·nant syn·drome

(nūr'ō-lep'tik mă-lig'nănt sin'drōm)
Hyperthermia with extrapyramidal and autonomic disturbances that may result in death, following the use of neuroleptic agents.

neuroleptic malignant syndrome

A rare and sometimes fatal disorder related to the use of any NEUROLEPTIC drug in any dosage. It features high fever, sweating, severe rigidity of muscles, wide swings of blood pressure, incontinence, confusion and coma.
References in periodicals archive ?
Neuroleptic malignant syndrome: A case aimed at raising clinical awareness.
Atypical neuroleptic malignant syndrome and atypical antipsychotics.
(3.) Yang, Y., Yahui, G., Zhang, A., Neuroleptic malignant syndrome in a patient treated with lithium carbonate and haloperidol, Shanghai Arch Psychiatry.
Francis, "Catatonic signs in neuroleptic malignant syndrome," Comprehensive Psychiatry, vol.
Heiman-Patterson, "Neuroleptic malignant syndrome and malignant hyperthermia.
Neuroleptic malignant syndrome associated with atypical antipsychotic drugs.
Neuroleptic malignant syndrome (NMS) is a rare, but potentially life-threatening adverse reaction to antipsychotic drugs and other dopamine-modulating agents.
Atypical neuroleptic malignant syndrome: diagnosis controversies and considerations.
Neuroleptic malignant syndrome (NMS) represents a cluster of adverse effects of antipsychotic medications including: hypertonicity, autonomic instability, fever, and cognitive disturbance.
Like similar drugs, it has many other serious potential risks, including strokes, heart problems, high blood sugar and diabetes, suicide, seizures, fainting, a drop in infection-fighting white blood cells, sedation and impaired thinking, and neuroleptic malignant syndrome, a life-threatening neurological disorder.
The notice emphasized that treatment should not be abruptly discontinued, because rapid withdrawal of dopamine agonists has been associated with a syndrome resembling neuroleptic malignant syndrome or akinetic crises.