ACE is responsible for degeneration of neurokinins
that play an important role in regulation of emotions.
Substance P (SP) is considered as the prototypic neuropeptide of the more than 50 known neuroactive molecules, and is also the member of a new neurotransmitter system that belongs to the family of three related peptides known as neurokinins
and a member of the seven-transmembrane G-protein coupled family of receptors and is primarily associated with sensory neurons in the periphery and specific areas of the CNS [1,2].
Pernow, "Research on tachykinins: clinical trends, " in Substance P and Neurokinins, pp.
Awawdeh and colleagues  evaluated 20 patients, half of which were affected by periodontal disease, the concentrations of SP and neurokinin A (NKA).
Lamey, "Quantitative analysis of substance P, neurokinin A and calcitonin gene-related peptide in gingival crevicular fluid associated with painful human teeth, " The European journal of oral sciences, vol.
"Manipulation of neurokinin receptors may have a downstream effect on serotonergic and noradrenergic transmission," said Dr.
The compound is highly selective for the subpopulation of neurokinin receptors (NK-1) that correspond to substance P.