neurokinin-1 antagonist

neurokinin-1 antagonist (NK1),

agent that blocks the action of substance Pm which is a peptide found in the brain and GI tract, which initiates its actions by binding to the neurokinin-1 receptor. Antagonists of the neurokinin-1 receptor have been shown to have antiemetic activity.
See also: substance P.
Farlex Partner Medical Dictionary © Farlex 2012
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Comparison of the neurokinin-1 antagonist GR205171, alone and in combination with the 5-HT3 antagonist ondansetron, hyoscine and placebo in the prevention of motion-induced nausea in man.
Vertigo and motion sickness. Part II: pharmacologic treatment

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