B Receptor Antagonism in Women With Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Trial.
SP binds to neurokinin
receptors (NK) 1 and 2 of enteric cholinergic secretomotor neurons in submucosal ganglia.
B (endogenous ligand of TACR3) is involved in pathogenesis of Parkinson's disease by interacting with brain dopaminergic transmission .
B and the hypothalamic regulation of reproduction," Brain Research, vol.
Todd, "GABAergic neurons that contain neuropeptide Y selectively target cells with the neurokinin
I receptor in laminae III and IV of the rat spinal cord," Journal of Neuroscience, vol.
(PGE2 stimulates the release of tachykinins, which stimulate neurokinin
receptors on afferent nerves and detrusor smooth muscle, and as a result, promote detrusor contraction.) General Increases 1.
Substance P induces vomiting and binds to neurokinin
1 (NK-1) receptors in the abdominal vagus, the nucleus tractus solitarius, and the area postrema.
(3) BDNF: Brain-derived neurotrophic factor; CRH: Corticotropin- releasing hormone; DA: Dopamine; GABA: Gamma aminobutyric acid; NE: Norepinephrine; NK: Neurokinin
; NMDA: N-methyl-D-aspartate; PAP: 3'(2')-phosphoadenosine-5'-phosphate.
SP is a member of the tachykanin family of neuropeptides, also known as the neurokinin
. Two other tachykinin is known to exist, neurokinin
A (NKA) and neurokinin
In addition, researchers are evaluating the therapeutic potential of corticotrophin-releasing factor antagonists and neurokinin
1 antagonists, which may address the relationship between stress and alcohol consumption.
In Chapter 10, the authors review the genetics of neurokinin
B and its receptor and their role in the regulation of human GnRH secretion in hypogonadotropic hypogonadism (HH).