neurokinin


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neurokinin

(noor″ō-kī′nĭn) [ neuro- + kinin],

NK

Any of a group of neuropeptides found in the central nervous system that stimulate nerve receptors and cause smooth muscle contraction, blood pressure reduction, and bronchoconstriction.

neurokinin (A) (nŏŏ´ōkī´nin),

n a mammalian deca-peptide tachykinin found in the central nervous system. The compound has bronchoconstrictor, smooth muscle constrictor, and hypotensive effects and also activates the micturition reflex.
References in periodicals archive ?
Morrish, "Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and preeclampsia," Molecular Human Reproduction, vol.
PGE2 stimulates the release of tachykinins, which stimulate neurokinin receptors on afferent nerves and detrusor smooth muscle, and as a result, promote detrusor contraction.
Inflammation-induced upregulation of neurokinin 1 receptors in rat glabrous skin.
12) George DT, Gilman J, Hersh J, et al: Neurokinin 1 receptor antagonism as a possible therapy for alcoholism.
Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B.
Alterations of neurokinin receptors and interstitial cells of Cajal during and after jejunal inflammation induced by Nippostrongylus brasiliensis in the rat.
Newer agents are currently being explored in phase II trials: cholecystokinin antagonists, (113) [alpha]2 adrenergic agonists (clonidine), (114) k-opioid agonists (fedotozine), (115-117) a SSRI (citalopram), (118) and neurokinin antagonists.
neurokinin A and substance P) mediate excitatory non-adrenergic, non-cholinergic transmission, which cause broncho-constriction and bronchial hyperresponsiveness.
The wide variety of drugs in development includes opioid receptor ligands, bradykinin antagonists, newer COX inhibitors, glutamate receptor antagonists, substance P and neurokinin receptor antagonists, P2X2 neuron receptor antagonists and nitric oxide-based analgesics.
4) Substance P (SP), neurokinin A, neurotensin, vasoactive intestinal peptide (VIP), neuropeptide Y and calcitonin gen-related peptide (CGRP).