Thus, the vagus nerve could affect cancer via afferent-central
neuroimmunomodulation as well.
According to the
neuroimmunomodulation theory of AD, the earliest CNS changes before the clinical onset of AD result from a chronic inflammatory response, which leads to abnormal tau phosphorylation and induces formation of PHFs and tau protein aggregates, ultimately resulting in cytoskeletal alterations [50].
Souza et al., "Estradiol, but not dehydroepiandrosterone, decreases parasitemia and increases the incidence of cerebral malaria and the mortality in Plasmodium berghei ANKA-infected CBA mice,"
Neuroimmunomodulation, vol.
Given the possible role of the vagus nerve in modulating cancer via inhibiting inflammation [21], we developed a simple numerical ratio indexing vagal
neuroimmunomodulation (NIM) of inflammation.
The two abstracts have been included as supplements, and the data of the publications are the following: Regen Med 2013; 8 (6s):S81-S81 and
Neuroimmunomodulation 2014; 21 (Suppl 1): S7-S7.
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