Thus, the vagus nerve could affect cancer via afferent-central neuroimmunomodulation
According to the neuroimmunomodulation
theory of AD, the earliest CNS changes before the clinical onset of AD result from a chronic inflammatory response, which leads to abnormal tau phosphorylation and induces formation of PHFs and tau protein aggregates, ultimately resulting in cytoskeletal alterations .
Souza et al., "Estradiol, but not dehydroepiandrosterone, decreases parasitemia and increases the incidence of cerebral malaria and the mortality in Plasmodium berghei ANKA-infected CBA mice," Neuroimmunomodulation
Given the possible role of the vagus nerve in modulating cancer via inhibiting inflammation , we developed a simple numerical ratio indexing vagal neuroimmunomodulation
(NIM) of inflammation.
The two abstracts have been included as supplements, and the data of the publications are the following: Regen Med 2013; 8 (6s):S81-S81 and Neuroimmunomodulation
2014; 21 (Suppl 1): S7-S7.
Rampton, "The Role of Psychological Stress in Inflammatory Bowel Disease," Neuroimmunomodulation
Allahtavakoli, "The possible role of toll-like receptor 4 in the pathology of stroke," Neuroimmunomodulation
Hassanshahi, "Significant role(s) of CXCL12 and the SDF-1 3' a genetic variant in the pathogenesis of multiple sclerosis," Neuroimmunomodulation
Banks, "Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier," NeuroImmunoModulation
Ghosh, "Effects of naproxen on immune responses in a colchicine-induced rat model of Alzheimer's disease," NeuroImmunoModulation
. 2005;12:131-40, http://dx.doi.org/10.1159/000084844.
Vredevoe, "Beta blocker and angiotensin-converting enzyme inhibitor therapy is associated with decreased Th1/Th2 cytokine ratios and inflammatory cytokine production in patients with chronic heart failure," NeuroImmunoModulation