The isolated working heart preparation permits characterization of cardiac function without compounding effects of (i) neurohumoral
activity (ii) anesthesia (iii) changing in loading parameters (iv) influence of other organs/systems and (v) a preparation which yields more information on functional performance of the heart than Langendorff's preparation .
Such phenomena predispose to ventricular remodeling by neurohumoral
activation and an increase in electrical excitability, elements that are progressively associated to a higher incidence of sudden death in this group of patients.
Balteanu, (Romanian Journal of Physical Therapy, 2006) considers that breathing has mechanical, reflex and neurohumoral
effects on cardiovascular risks by intensity, frequency and technique.
Chronic heart failure is associated with systemic inflammation, oxidative stress, cytokine production, and neurohumoral
activation, leading to enhanced catecholamine release and sympathetic activation .
Recently, the link between these peripheral systems activated in HF and the central nervous system (CNS) as a source of neurohumoral
drive has been well established.
One of the manifestations of portal hypertension is hyperdynamic circulatory state due to activation of neurohumoral
pathways that stimulate renal sodium retention, expansion of plasma volume.
features of myocardial stunning due to sudden emotional stress.
Apparent paradox of neurohumoral
axis inhibition after body fluid volume depletion in patients with chronic congestive heart failure and water retention.
This implied that leptin serum level was influenced by not only changes in fat mass distribution but also neurohumoral
regulation after SCI.
Nevertheless, after this stage, longstanding biochemical, biomechanical, neurohumoral
, and inflammation responses lead to structural damage of the pancreas (chronic pancreatitis) and a lowering of the exocrine pancreatic function while bringing many accompanying digestive diseases.
Conversely, Sato and colleagues (2013) demonstrated that alcohol aggravates hemorrhagic shock in a dose-dependent manner not by triggering an immune response but by suppressing hormonal and neurohumoral
responses, thereby inhibiting hemodynamic auto-regulation and shortening the survival interval.
Aun asi, este es el pilar fundamental del tratamiento junto con el bloqueo neurohumoral
para el manejo de la falla cardiaca (15).