neuroglobin


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neuroglobin

A monomeric, intracellular haemoprotein encoded by NGB on chromosome 14q24.3, which is present in the central and peripheral nervous systems, CSF, retina and endocrine tissues, and involved in oxygen homeostasis. It reversibly binds oxygen with an affinity higher than that of haemoglobin, increases oxygen availability to the brain via nitric oxide and protects the brain during hypoxia and ischaemia, improving neurone survival and recovery.

neuroglobin

An oxygen-transport material in the brain analogous to haemoglobin in the blood and myoglobin in the muscles. Neuroglobin is a small protein of 151 amino acids. It is thought to have a neuroprotective effect in cerebral ischaemia, but its full function remains unelucidated.
References in periodicals archive ?
Transgenic overexpression of neuroglobin attenuates formation of smoke-inhalation-induced oxidative DNA damage, in vivo, in the mouse brain.
Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin.
The scientists think a molecule called neuroglobin might be important.
neuroglobin A recently discovered molecule that is related to hemoglobin and myoglobin.
Washington, August 3 (ANI): Researchers from the University of California, Davis, and the University of Auckland have found that neuroglobin may protect against Alzheimer's disease by preventing brain neurons from dying in response to natural stress.
Scientists have learned that neuroglobin protects cells from stroke damage, amyloid toxicity and injury due to lack of oxygen.
Scientists discovered the hemoglobin cousin several years ago and dubbed it neuroglobin because only nerve cells in the brain of vertebrates make it.
The amount of brain tissue damaged by the strokes was significantly less in those animals than in rats not given the virus, or in rats whose brains had less-than-normal amounts of neuroglobin, the investigators report in the March 18 Proceedings of the National Academy of Sciences.
Washington, May 7 (ANI): For the first time, scientists have found that the variation in a gene, responsible for the production of a protein called neuroglobin, is linked with an increased risk of Alzheimer's Disease (AD).
For the study, researchers at the McKusick-Nathans Institute of Genetic Medicine of the Johns Hopkins University School of Medicine analysed the genetic neighbourhood of neuroglobin.
Two years ago, however, a third vertebrate globin was discovered in the human brain and named neuroglobin.