neuroglobin


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neuroglobin

A monomeric, intracellular haemoprotein encoded by NGB on chromosome 14q24.3, which is present in the central and peripheral nervous systems, CSF, retina and endocrine tissues, and involved in oxygen homeostasis. It reversibly binds oxygen with an affinity higher than that of haemoglobin, increases oxygen availability to the brain via nitric oxide and protects the brain during hypoxia and ischaemia, improving neurone survival and recovery.

neuroglobin

An oxygen-transport material in the brain analogous to haemoglobin in the blood and myoglobin in the muscles. Neuroglobin is a small protein of 151 amino acids. It is thought to have a neuroprotective effect in cerebral ischaemia, but its full function remains unelucidated.
References in periodicals archive ?
Expression and role of neuroglobin in rats with sepsis-associated encephalopathy.
Neuroglobin, a protein that needs to be identified by in-depth research lab, and cannot be detected by current MS-based proteomics technology (54).
2010: Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax.
Like neuroglobin and cytoglobin in our brain, GLB-5 is expressed in neurons.
CYGB is the fourth member of the globin family, which previously consisted of hemoglobin (Hb, first member), myoglobin (Mb, second), and neuroglobin (Ngb, third), whose common feature is their high affinity for molecular oxygen ([O.
Transgenic overexpression of neuroglobin attenuates formation of smoke-inhalation-induced oxidative DNA damage, in vivo, in the mouse brain.
The scientists think a molecule called neuroglobin might be important.
Washington, August 3 (ANI): Researchers from the University of California, Davis, and the University of Auckland have found that neuroglobin may protect against Alzheimer's disease by preventing brain neurons from dying in response to natural stress.
Although the first papers were written in 19th century, today a lot of amazing discoveries are shown, like new globins neuroglobin and cytoglobin and, nitric oxide interactions.
Scientists discovered the hemoglobin cousin several years ago and dubbed it neuroglobin because only nerve cells in the brain of vertebrates make it.
Washington, May 7 (ANI): For the first time, scientists have found that the variation in a gene, responsible for the production of a protein called neuroglobin, is linked with an increased risk of Alzheimer's Disease (AD).