in the adult brain involved not only the proliferation and migration of precursor cells known as stem cells/neural progenitor cells (NSCs) but also their functional integration into the neural network.
The new discovery of how RMST works within a gene regulatory network not only sheds light on the process of neurogenesis
, but also generates new insight into how lncRNA works together with protein components to regulate the important biological processes of gene expression.
KEY WORDS: bipolar cells, development, gestational exposure, glia, lead, mice, neurogenesis
, proliferation, retina, rod photoreceptors.
A two- to threefold increase in hippocampal neurogenesis
has been observed in rats with regular access to a running wheel versus control animals.
2000, 2004) and when neurogenesis
is inhibited (Crews et al.
In the study of 347 patients with colorectal cancer, Kaplan-Meier curves showed that those with stage III cancer and no evidence of neurogenesis
achieved significantly greater cancer-specific overall survival at 5 years than did those with stage II cancer and a high degree of neurogenesis
Now that we know that lead decreases neurogenesis
in the hippocampus and alters the ability of these new neurons to communicate, in future studies we hope to determine if environmental enrichment can reverse these detrimental effects of lead.
This has profound implications for the future management of depression, because the efficacy of an antidepressant therapy may depend, in part, on its ability to induce neurogenesis
in the hippocampus, Jason Scalia, Ph.
Put them in metal cages, kill them, and slice their brains for microscopy, and you find very little neurogenesis
Although FAK has been studied in short-term focal adhesion turnover, research into FAK's role in adhesion during long-term neurogenesis
has been limited.
The L1CAM is typically expressed on neural cells and plays an important role in neurogenesis
, nerve growth, and neuron-to-neuron adhesion.
Approaches to Study Neurogenesis
in the Zebrafish Retina