The prevalence of adult
neurogenesis in humans and primates is an area of active discussion in the field and more research is needed to determine whether the process of stem cell generation observed in the mouse pertains to other mammals too.
Neurogenesis was demonstrated by detecting an increased number of cells containing Ki67, a marker of dividing cells, scored by scientists blinded to the treatment groups.
[16] Our results showed that EPO has a significant effect on
neurogenesis in the granular zone of dentate gyrus in Alzheimer's rats.
Adult
neurogenesis in the hippocampus is critical to learning and memory, but how conditions such as Alzheimer's affect this process isn't well understood.
It was here where they discovered that
neurogenesis persists even among the elderly, and does not stop in adolescence: 'We found there were on the other of thousands of neuroprogenitor cells and immature neutrons both in the youngest and the oldest people analyzed.'
These results indicate that GLe can promote adult
neurogenesis in the DG of the hippocampus and that increases of BDNF and TrkB expressions in the DG following GLe treatment might be closely associated with neurogenic effects of GLe.
Increased
Neurogenesis Does Not Underlie Cognitive Improvement after Cell Implantation.
In his book, Cortright points to research showing that
neurogenesis is "the most important biomarker for brain health most people never heard of." While a low rate of
neurogenesis is linked with mental disorders such as anxiety, depression, stress, and cognitive deficits, a high rate of
neurogenesis has only positive effects--lowered stress, anxiety and depression, plus enhanced cognitive abilities including faster learning and better problem-solving skills.
The level of stress response was found to be inversely related to the level of
neurogenesis in the hippocampus.
TJZL184, a monoacylglycerol lipase inhibitor, exhibited antidepressant effects by enhancing adult
neurogenesis and long-term synaptic plasticity in the dentate gyrus of the hippocampus [15].
As a result, a number of naturally occurring dietary antioxidants have been identified with properties that support
neurogenesis. The role of antioxidants has also been implicated in the functional outcomes in ageing and neurodegenerative disorders and their protective role is clearly linked to such outcomes in the abovementioned studies.
When
neurogenesis occurs, several types of progenitor cells are observed.
