neurofibrillary tangle
Also found in: Encyclopedia, Wikipedia.
neu·ro·fi·bril·la·ry tan·gle
intraneuronal accumulations of helical filaments that assume twisted contorted patterns; found in cells of the hippocampus and cerebral cortex in patients with Alzheimer disease.
Farlex Partner Medical Dictionary © Farlex 2012
neurofibrillary tangle
A characteristic histologic finding in the perikaryon of large cortical neurones of patients with Alzheimer’s disease, which consists of fibrilised protein derived from microtubule-associated protein tau. The number of NFTs loosely correlates with the severity of dementia.DiffDx
Down’s syndrome, subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, Hallervorden-Spatz disease, lipofuscinosis, post-encephalitic parkinsonism, and normal adults (confined to the hippocampus).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
neurofibrillary tangle
Neuropathology A characteristic histologic finding in the perikaryon of large cortical neurons of Pts with Alzheimer's disease, the number of NFTs loosely correlates with the severity of dementia DiffDx Down's syndrome, subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, Hallervorden-Spatz disease, lipofuscinosis, post-encephalitic parkinsonism, and normal adults–confined to the hippocampus. See Alzheimer's disease, Amyloid plaque, Granulovacuolar degeneration, Paired helical filaments, Senile plaques.McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
Neurofibrillary tangle
—Twisted masses of protein inside nerve cells that develop in the brains of people with AD.
Mentioned in: Alzheimer's Disease
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.