neurofibrillary tangle


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neu·ro·fi·bril·la·ry tan·gle

intraneuronal accumulations of helical filaments that assume twisted contorted patterns; found in cells of the hippocampus and cerebral cortex in patients with Alzheimer disease.
Farlex Partner Medical Dictionary © Farlex 2012

neurofibrillary tangle

A characteristic histologic finding in the perikaryon of large cortical neurones of patients with Alzheimer’s disease, which consists of fibrilised protein derived from microtubule-associated protein tau. The number of NFTs loosely correlates with the severity of dementia.
 
DiffDx
Down’s syndrome, subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, Hallervorden-Spatz disease, lipofuscinosis, post-encephalitic parkinsonism, and normal adults (confined to the hippocampus).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

neurofibrillary tangle

Neuropathology A characteristic histologic finding in the perikaryon of large cortical neurons of Pts with Alzheimer's disease, the number of NFTs loosely correlates with the severity of dementia DiffDx Down's syndrome, subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, Hallervorden-Spatz disease, lipofuscinosis, post-encephalitic parkinsonism, and normal adults–confined to the hippocampus. See Alzheimer's disease, Amyloid plaque, Granulovacuolar degeneration, Paired helical filaments, Senile plaques.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

Neurofibrillary tangle

—Twisted masses of protein inside nerve cells that develop in the brains of people with AD.
Mentioned in: Alzheimer's Disease
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
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References in periodicals archive ?
Thus, the integrated effect of PKC activation on the complete amyloidogenic and neurofibrillary tangle pathways is to inhibit and prevent the pathologic hallmarks of AD.
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"Together, the sex difference in the association between APOE and CSF measures of tau and the lack of a sex difference in the association with neurofibrillary tangles at autopsy suggest that APOE may modulate risk for neurodegeneration in a sex-specific manner, particularly in the presence of amyloidosis," the authors write.
Women Have Stronger Link Between APOE-?4, CSF Tau Levels; Sex differences were not seen in the correlation between APOE and neurofibrillary tangle burden
Aggregation of abnormally phosphorylated tau, the main constituent of neurofibrillary tangles, is most likely a key pathological event of AD (7).
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In 1907, the German physician found microscopic bits of debris -- now called plaques and neurofibrillary tangles -- cluttering brain tissue taken from a 51-year-old woman who had suffered from dementia.
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Columbia University Medical Center (CUMC) researchers found that abnormal tau protein, a key feature of the neurofibrillary tangles seen in the brains of those with Alzheimer's, propagates along linked brain circuits, "jumping" from neuron to neuron.
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The trial will use Cerveau's [F-18]MK-6240, an investigational imaging agent to be used in Positron Emission Tomography scans for assessing the status and progression of neurofibrillary tangles in the brain.
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The researchers also discovered correlations between gene expression patterns and other measures of Alzheimer's severity such as the level of amyloid plaques and neurofibrillary tangles, as well as cognitive impairments.
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The presence of amyloid plaques and neurofibrillary tangles is not a sufficient condition for the clinical expression of dementia.
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The study met pre-specified endpoints with flortaucipir demonstrating statistically significant sensitivity and specificity for detecting tau pathology of Braak Stage V/VI, a pathological staging scale for tau neurofibrillary tangles. Flortaucipir also demonstrated statistically significant sensitivity and specificity for detecting a high level of total Alzheimer's disease neuropathologic change using the National Institute on Aging and Alzheimer's Association neuropathology criteria.
Lilly say study of flortaucipir PET imaging agent met its two primary endpoints

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