Mentioned in ?
References in periodicals archive ?
Thus, the integrated effect of PKC activation on the complete amyloidogenic and neurofibrillary tangle pathways is to inhibit and prevent the pathologic hallmarks of AD.
New developments in the search for a cure
"Together, the sex difference in the association between APOE and CSF measures of tau and the lack of a sex difference in the association with neurofibrillary tangles at autopsy suggest that APOE may modulate risk for neurodegeneration in a sex-specific manner, particularly in the presence of amyloidosis," the authors write.
Women Have Stronger Link Between APOE-?4, CSF Tau Levels; Sex differences were not seen in the correlation between APOE and neurofibrillary tangle burden
Aggregation of abnormally phosphorylated tau, the main constituent of neurofibrillary tangles, is most likely a key pathological event of AD (7).
Changes in tau phosphorylation levels in the hippocampus and frontal cortex following chronic stress
In 1907, the German physician found microscopic bits of debris -- now called plaques and neurofibrillary tangles -- cluttering brain tissue taken from a 51-year-old woman who had suffered from dementia.
A molecular whodunit: new twists in the Alzheimer's mystery
Columbia University Medical Center (CUMC) researchers found that abnormal tau protein, a key feature of the neurofibrillary tangles seen in the brains of those with Alzheimer's, propagates along linked brain circuits, "jumping" from neuron to neuron.
Alzheimer's spreads by 'jumping from one brain region to another'
Alzheimer's disease is a complex and devastating condition characterized by plaques of amyloid-[eth] and neurofibrillary tangles, also known as tau pathology, in the brain.
Alzheimer's Protein: Plaques, Cell Death in Mice
And according to research published earlier this year, being frail also means you may be less able to withstand the effects of Alzheimer's disease pathology--the formation of amyloid plaques around neurons and neurofibrillary tangles within neurons.
FRAILTY AND ALZHEIMER'S RISK... CHALLENGES OF MEDITATION... ASPIRIN AND BRAIN HEALTH
The trial will use Cerveau's [F-18]MK-6240, an investigational imaging agent to be used in Positron Emission Tomography scans for assessing the status and progression of neurofibrillary tangles in the brain.
Cerveau Technologies Forges Partnership with LuMind IDSC Foundation to Study Accumulation of Neurofibrillary Tau in Down Syndrome
The researchers also discovered correlations between gene expression patterns and other measures of Alzheimer's severity such as the level of amyloid plaques and neurofibrillary tangles, as well as cognitive impairments.
New study offers potential new drug targets for Alzheimer's
The presence of amyloid plaques and neurofibrillary tangles is not a sufficient condition for the clinical expression of dementia.
Frailty may affect the expression of dementia
The study met pre-specified endpoints with flortaucipir demonstrating statistically significant sensitivity and specificity for detecting tau pathology of Braak Stage V/VI, a pathological staging scale for tau neurofibrillary tangles. Flortaucipir also demonstrated statistically significant sensitivity and specificity for detecting a high level of total Alzheimer's disease neuropathologic change using the National Institute on Aging and Alzheimer's Association neuropathology criteria.
Lilly say study of flortaucipir PET imaging agent met its two primary endpoints

Medical browser ?
Full browser ?