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Thus, the integrated effect of PKC activation on the complete amyloidogenic and neurofibrillary tangle pathways is to inhibit and prevent the pathologic hallmarks of AD.
"Together, the sex difference in the association between APOE and CSF measures of tau and the lack of a sex difference in the association with neurofibrillary tangles at autopsy suggest that APOE may modulate risk for neurodegeneration in a sex-specific manner, particularly in the presence of amyloidosis," the authors write.
Aggregation of abnormally phosphorylated tau, the main constituent of neurofibrillary tangles, is most likely a key pathological event of AD (7).
In 1907, the German physician found microscopic bits of debris -- now called plaques and neurofibrillary tangles -- cluttering brain tissue taken from a 51-year-old woman who had suffered from dementia.
Columbia University Medical Center (CUMC) researchers found that abnormal tau protein, a key feature of the neurofibrillary tangles seen in the brains of those with Alzheimer's, propagates along linked brain circuits, "jumping" from neuron to neuron.
Alzheimer's disease is a complex and devastating condition characterized by plaques of amyloid-[eth] and neurofibrillary tangles, also known as tau pathology, in the brain.
And according to research published earlier this year, being frail also means you may be less able to withstand the effects of Alzheimer's disease pathology--the formation of amyloid plaques around neurons and neurofibrillary tangles within neurons.
The trial will use Cerveau's [F-18]MK-6240, an investigational imaging agent to be used in Positron Emission Tomography scans for assessing the status and progression of neurofibrillary tangles in the brain.
The researchers also discovered correlations between gene expression patterns and other measures of Alzheimer's severity such as the level of amyloid plaques and neurofibrillary tangles, as well as cognitive impairments.
The presence of amyloid plaques and neurofibrillary tangles is not a sufficient condition for the clinical expression of dementia.
The study met pre-specified endpoints with flortaucipir demonstrating statistically significant sensitivity and specificity for detecting tau pathology of Braak Stage V/VI, a pathological staging scale for tau neurofibrillary tangles. Flortaucipir also demonstrated statistically significant sensitivity and specificity for detecting a high level of total Alzheimer's disease neuropathologic change using the National Institute on Aging and Alzheimer's Association neuropathology criteria.