neurofibril

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neurofibril

 [noor″o-fi´bril]
one of the delicate threads running in every direction through the cytoplasm of a nerve cell, extending into the axon and dendrites.

neu·ro·fi·bril

(nū'rō-fī'bril),
A filamentous structure seen with the light microscope in the nerve cell's body, dendrites, axon, and sometimes synaptic endings, as aggregations of much finer ultramicroscopic elements, the neurofilaments and microtubules; their functional significance remains to be established.

neurofibril

/neu·ro·fi·bril/ (-fi´bril) one of the delicate threads running in every direction through the cytoplasm of a nerve cell and extending into the axon and dendrites in a silver-stained preparation; believed to be neurofilament bundles, and perhaps neurotubules, coated with silver.

neurofibril

(no͝or′ə-fī′brəl, -fĭb′rəl, nyo͝or′-)
n.
Any of the long, thin, microscopic fibrils that run through the body of a neuron and extend into the axon and dendrites.

neu′ro·fi′bril·lar′y (-brə-lĕr′ē) adj.

neurofibril

[-fī′bril]
a threadlike structure found in the cytoplasm of a neuron.

neu·ro·fi·bril

(nūr'ō-fī'bril)
A filamentous structure seen with the light microscope in the body, dendrites, axons, and sometimes synaptic endings of a nerve cell.

neurofibril

one of the delicate threads running in every direction through the cytoplasm of a nerve cell, extending into the axon and dendrites.
References in periodicals archive ?
Similarly, Bieloschsky silver impregnation revealed no clear pathology in the blank and saline groups, but neurofibrillary tangles in the treatment group (Fig.
HandE stained microscopic glass slides were reviewed by two pathologists and were analyzed for various histological features including growth pattern, architecture, neurofibrillary matrix, rosettes, nuclear pleomorphism, nucleoli, mitotic activity, necrosis and calcification.
Originally put forth in the mid-1980s, the amyloid hypothesis maintained that beta-amyloid deposits in the brain set off all subsequent events -- the neurofibrillary tangles that choke the insides of neurons, neuronal cell death, and inflammation leading to a vicious cycle of massive cell death," says Rudolph Tanzi, PhD, director of the MGH Genetics and Aging Research Unit and co-senior author of the report receiving advance online publication in Nature.
COPENHAGEN -- Detection of tau neurofibrillary tangles in the brain via PET imaging highly correlates with memory decline and could serve as an accurate way to identify individuals at high risk of Alzheimer's disease and track disease progression, according to the results of a prospective study.
Tau protein is the main component of neurofibrillary tangles, one of the hallmarks of Alzheimer's disease.
Additionally, there exists a variable presence (or absence) of true rosettes and neurofibrillary material.
Although they cannot be detected prior to autopsy, characteristic pathologic features of this disease include neurofibrillary tangle and plaque formation and changes in oxidative and inflammatory processes as well as cholinergic neurotransmission.
The imaging tool used in the study was developed at UCLA and reveals early evidence of amyloid beta plaques and neurofibrillary tau tangles in the brain--the hall-marks of Alzheimer's disease.
Alzheimer's disease (AD), the most common cause of dementia, is characterized by the presence of senile plaques and neurofibrillary tangles, surrounded by damaged neurons.
One of the hallmarks of Alzheimer's disease is the aggregation of a protein called tau, which in turn gives rise to neurofibrillary tangles (NFT) and impairs brain function.
These changes include increased levels of amy-loid-beta42 in the blood and decreased levels in the cerebrospinal fluid, compared with noncarriers (reflecting the presence of amyloid plaques in the brain) and elevated levels of tau and phosphorylated tau in the cerebrospinal fluid, compared with noncarriers (reflecting the presence of neurofibrillary tangles and/or brain cell death).