neurofibril

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Related to neurofibrillary: neurofibrillary degeneration, Neurofibrillary tangles

neurofibril

 [noor″o-fi´bril]
one of the delicate threads running in every direction through the cytoplasm of a nerve cell, extending into the axon and dendrites.

neu·ro·fi·bril

(nū'rō-fī'bril),
A filamentous structure seen with the light microscope in the nerve cell's body, dendrites, axon, and sometimes synaptic endings, as aggregations of much finer ultramicroscopic elements, the neurofilaments and microtubules; their functional significance remains to be established.

neurofibril

/neu·ro·fi·bril/ (-fi´bril) one of the delicate threads running in every direction through the cytoplasm of a nerve cell and extending into the axon and dendrites in a silver-stained preparation; believed to be neurofilament bundles, and perhaps neurotubules, coated with silver.

neurofibril

(no͝or′ə-fī′brəl, -fĭb′rəl, nyo͝or′-)
n.
Any of the long, thin, microscopic fibrils that run through the body of a neuron and extend into the axon and dendrites.

neu′ro·fi′bril·lar′y (-brə-lĕr′ē) adj.

neurofibril

[-fī′bril]
a threadlike structure found in the cytoplasm of a neuron.

neu·ro·fi·bril

(nūr'ō-fī'bril)
A filamentous structure seen with the light microscope in the body, dendrites, axons, and sometimes synaptic endings of a nerve cell.

neurofibril

one of the delicate threads running in every direction through the cytoplasm of a nerve cell, extending into the axon and dendrites.
References in periodicals archive ?
While the mouse models of Alzheimer's disease that express the gene variants causing the inherited early-onset form of the disease do develop amyloid plaques in their brains and memory deficits, the neurofibrillary tangles that cause most of the damage do not appear.
Neurofibrillary tangles (NFTs) in AD brain are consist of paired helical filaments (PHFs), which are mainly composed of hyperphosphorylated tau protein (Maccioni et al.
These changes include increased levels of amy-loid-beta42 in the blood and decreased levels in the cerebrospinal fluid, compared with noncarriers (reflecting the presence of amyloid plaques in the brain) and elevated levels of tau and phosphorylated tau in the cerebrospinal fluid, compared with noncarriers (reflecting the presence of neurofibrillary tangles and/or brain cell death).
The major pathologic findings in the AD brain at autopsy are amyloid plaques (extracellular), neurofibrillary tangles (intracellular), and the loss of synaptic connections.
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.
The plaques, along with neurofibrillary tangles, are thought to contribute to the degradation of the wiring in brain cells and lead to the symptoms of Alzheimer's disease.
Exposure to high levels of aluminium (Al) leads to neurofibrillary degeneration and that Al concentration is increased in degenerating neurons in Alzheimer's disease (AD).
This collection of 14 extended articles describes the latest research, starting with work related to Alzheimer's disease, covering improving cholinergic transmission, reduction in plaque formation, carbonic anhydrase activators as potential anti-disease agents, detection and reduction of neurofibrillary lesions, protein folding as protection or pathogen, and the effects of the enhancement of brain retinoic acid levels.
Neuroendocrine carcinoma (NEC) was first proposed as a clinical entity by Silva et al in 19822 It is a rare malignant neoplasm that contains neurosecretory granules and lacks a neurofibrillary background.
Scientists had shown that mice subjected to extreme stress--whether by forced swimming in cold water, starvation, or heat--develop clumps of insoluble proteins called neurofibrillary tangles in their neurons.
Experts believe that the formation of amyloid plaques and neurofibrillary tangles contribute to the degradation of the nerve cells in the brain and the subsequent symptoms of Alzheimer's disease.
The two typical histopathologic features are a) plaques, which are clumps of insoluble [beta]-amyloid protein fragments that accumulate extracellularly, and b) intracellular neurofibrillary tangles composed of altered tau protein (Alzheimer's Association 2003).