Its roof plate appeared as a single layer of
neuroepithelial ependymal cells which covered by tela choroidea (vascular mesenchyme and the pia mater).
Dominguez, "Conserved miR-8/miR-200 defines a glial niche that controls
neuroepithelial expansion and neuroblast transition," Developmental Cell, vol.
Moreover, unspecific [[sup.18]F]-FET uptake has also been observed in nonspecific brain lesions [10, 11], and a lack of [[sup.18]F]-FET uptake does not exclude a glioma, as approximately onethird of WHO grade II gliomas and most dysembryoplastic
neuroepithelial tumors are [[sup.18]F]-FET negative [12].
Nestin, an intermediate filament protein, is a marker of a
neuroepithelial stem cell.
They are composed of poorly differentiated
neuroepithelial cells and are associated with a high risk of metastases through cerebrospinal fluid dissemination.
Nevertheless, progress has been made in defining the relationship between neurodevelopmental biology and
neuroepithelial tumors, perhaps most remarkably to date in the context of medulloblastoma, (37-41) as well as the relationship between
neuroepithelial progenitor cells, differentiated cells, and neoplasia in the adult human brain.
Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic
neuroepithelial tumour and dysgenesis of the archicortex in epilepsy.
In the vertebrate brain, postmitotic neurons are generated from
neuroepithelial cells and they start to extend long axonal processes and relatively short, branched dendrites after their migration to appropriate brain regions.
According to the WHO, it is an entity of unknown origin, separate from
neuroepithelial tumors [45].
Malignant transformation of
neuroepithelial cells is a multistep process driven by the sequential acquisition of genetic alterations.
Monzel et al., "Derivation of Human Midbrain-Specific Organoids from
Neuroepithelial Stem Cells," Stem Cell Reports, 2017; DOI: 10.1016/j.stemcr.2017.03.010
Wang, "A functional and protein-protein interaction analysis of
neuroepithelial cell transforming gene 1 in hepatocellular carcinoma," Tumor Biology, vol.
