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Ross had undergone brain surgery and chemotherapy after being diagnosed with a rare grade-4 primitive neuroectodermal tumour (PNET) in 2014.
(1) It is characterized by the histologic combination of malignant teratoma and carcinosarcoma with a triphasic growth pattern including epithelial, mesenchymal and primitive neuroectodermal components (2), and it mainly occurs in the nasal cavity and paranasal sinuses, although tumours occurring at other locations like nasopharynx and oral cavity have also been described.
Histologically, the mass was diagnosed as a teratoma with stratified squamous epithelial and neuroectodermal components.
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, rapidly growing, pigmented neoplasm of neural crest origin first described in 1918, (1) with slightly more than 500 reported cases to date.
nicely described the clinical picture, management plan, and outcome of a Taiwanese patient with primary uterine primitive neuroectodermal tumor (PNET).[1] I presume that the rarity of the condition and its escalating course with peritoneal seeding and liver metastasis should trigger the authors to consider altered immune status in the studied patient.
The differential diagnosis of lesions presenting with cutaneous involvement (ordered most to least common) include: leukemia, Langerhans cell histiocytosis, neuroblastoma, rhabdoid tumor, rhabdomyosarcoma, primitive neuroectodermal tumor, choriocarcinoma, and adrenocortical carcinoma.
Congenital sacrococcygeal primitive neuroectodermal tumor.
Primitive neuroectodermal tumors (PNETs), which are known as Ewing's sarcoma (ES), are high-grade malignant neoplasms that develop from a group of neuroectodermal small round cells' (1)'.
It consists of differentiated neuroectodermal tissue outside the central nervous system (2).
Immature teratoma can be excluded on the basis of age as these tumours most commonly occur in the first three decades of life and are almost nonexistent after menopause, and contain embryonal neuroectodermal elements and endodermal derivates in almost all cases.