neurodegeneration


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neurodegeneration

selective degeneration of neurons; may be entire neuron (neuronopathy) or restricted to the axon (axonopathy); may also be central, or peripheral, or central and peripheral.
References in periodicals archive ?
After 10 days of age, the manipulations reduced the distance flies could climb up tubes and the alterations caused older flies to have signs of neurodegeneration, including higher than normal levels of brain cell death and degradation.
Brookmeyer said, determined rates of progression from MCI to Alzheimer's dementia, given two preclinical states: asymptomatic amyloid brain plaques alone, or plaques with evidence of neurodegeneration and cognitive signs.
Stage 2: Amyloid positivity and evidence of synaptic dysfunction and/or early neurodegeneration in the presence of normal cognition.
Alpha-synuclein is a protein that has been hypothesised to be associated with the neurodegeneration and gastrointestinal dysfunction common in Parkinson's disease, however the exact cause is unknown.
However, all therapies are currently limited to lowering eye pressure, and research is underway to develop new drugs that directly target RGC neurodegeneration.
Our results suggested that exposure PTZ induce neurodegeneration, whereas, the treatment of metformin provide protection against the neuronal loos induced by PTZ can be used as therapeutic approaches for protection in adult neuronal cell culture.
The company is focused on innovative small-molecule research and development in the field of neurodegeneration, yielding new treatment options for patients with severe neurological diseases.
Pantothenate kinase-associated neurodegeneration (PKAN), account for up to 50% of cases, and are most commonly caused by autosomal recessive mutations in the PANK2 gene.
sup][12],[13] These findings suggest that, at least in some patients, neurodegeneration antedates the microcirculatory abnormalities that occur in DR, and in some respects, the early stages of DR could be considered a neuropathy rather than simply a microangiopathy.
5-million grant awarded for the creation of the Canadian Consortium on Neurodegeneration in Aging in 2014 by the federal government through the Canadian Institutes of Health Research.
The sign is considered the distinctive radiologic feature of Neurodegeneration with Brain Iron Accumulation (NBIA) type 1, also known as pantothenate kinase associated neurodegeneration (PKAN).
Results from two independent research groups on an important new mouse model of an inherited amyotrophic lateral sclerosis (ALS) gene indicate that development of disease pathology precedes neurodegeneration, and can be reversed by therapies targeting the mutant gene responsible for the pathology.