neurodegeneration


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neurodegeneration

selective degeneration of neurons; may be entire neuron (neuronopathy) or restricted to the axon (axonopathy); may also be central, or peripheral, or central and peripheral.
References in periodicals archive ?
We recently discovered the mechanism by which protein misfolding leads to neurodegeneration in prion disease.
In SA, disorders associated with neurodegeneration such as traumatic brain injury (TBI), alcohol dependence and HIV infection are affecting increasing numbers of older adults.
They identified a depletion of TDP-43 from the cell nuclei before any signs of neurodegeneration occurred, signifying that this loss may be a direct cause of the cell death associated with FTD.
He said: "We now know that neurodegeneration can be linked to changes taking place in parts of the body seemingly unrelated to the brain and many years before dementia is diagnosed.
It appears that certain individuals with a genetic predisposition toward a 'bad' neuroinflammatory response have neurodegeneration.
He told the BBC that a cure for Alzheimer's was not imminent, but 'I'm very excited, it's the first proof in any living animal that you can delay neurodegeneration.
A recent issue of the Journal of Neuroscience reports an association between a calorie-restricted diet and a delay in the decline in brain function that occurs in a mouse model of neurodegeneration.
Among the findings inconsistent with the proposed NIA-AA mode, "29% of the MCSA subjects and 17% of the ADNI-1 subjects had evidence for neurodegeneration without amyloid deposition," the authors wrote.
The investigators obtained data on biomarkers of amyloidosis (abnormal amyloid-beta-42 [A-beta-42] in cerebrospinal fluid) and neurodegeneration (hippocampal atrophy on MRI measured with FreeSurfer software, temporo-parietal hypometabolism measured with 18-fluorodeoxyglucose [18-FDG]-PET, and abnormal tau protein levels in cerebrospinal fluid).
These findings," declares Ule, "indicate that studies of healthy aging could help unravel the processes that lead to neurodegeneration.
EVIDENCE OF IIIALAMIC NEURODEGENERATION IN HUNTINGTON'S DISEASE MOUSE MODELS.
Nigral dopaminergic neurodegeneration, [alpha]-syn pathology, and neuroinflammation were then evaluated.