Down-regulation of neurocan
expression in reactive astrocytes promotes axonal regeneration and facilitates the neurorestorative effects of bone marrow stromal cells in the ischemic rat brain.
The aggrecanase and proteoglycanase clades (ADAMTS1, 4, 5, 8, 9, 15, and 20) can cleave hyaluronan-binding chondroitin sulfate proteoglycans, a type of extracellular proteins, including aggrecan, versican, brevican, and neurocan
Chondroitin sulfate proteoglycans (CSPGs), including the lecticans aggrecan, versican, neurocan
, and brevican, are joined to the hyaluronic acid polymer through "link" proteins including cartilage link protein (Crtl1).
Transplantation of HGF-overexpressing MSCs markedly decreased Neurocan
expression and glycosaminoglycan chain deposition around hemisection lesions in the spinal cord.
Marquezini et al., "Bevacizumab reduces neurocan
content and gene expression in newborn rat retina in vitro," Investigative Ophthalmology & Visual Science, vol.
is upregulated in injured brain and in cytokine-treated astrocytes.
The proteoglycans aggrecan, versican, neurocan
and brevican make up one such group based on their structural and functional similarities.
The study identified evidence for association with markers in the neurocan
gene (NCAN) on chromosome 19p12, and rs2501843 on chromosome 1.
The genetic variants examined included PNPLA3 (patatin-like phospholipase domain-containing protein 3), NCAN (neurocan
), LYPLAL1 (lysophospholipase-like 1), GCKR (glucokinase regulatory protein), and PPP1R3B (protein phosphatase 1), regulatory subunit 3b.
A recent study  found genome-wide significant association between common variation in the gene neurocan
(NCAN, rs1064395) and BD.
Other loci identified are near methylmalonic aciduria type B1/mevalonate kinase (MVK-MMAB) and UDP acetylgalactosaminyltransferase 2 (GALNT2), with high-density lipoprotein (HDL) cholesterol; near sortilin 1 (SORT1), cadherin EGF LAG seven-pass G-type receptor 2 (CELSR2) and Proline/serine-rich coiled-coil protein 1 (PSRC1) with variants primarily associated with low-density lipoprotein (LDL) cholesterol; near Tribbles homolog 1 (TRIB1), MLX interacting protein like1 (MLXIPL) and angiopoietin-like 3 (ANGPTL3), with variants primarily associated with triglycerides; and a locus encompassing several genes near neurocan
(NCAN), with variants strongly associated with both triglycerides and LDL cholesterol (74,75).
There are also a number of CSPGs, including brevican, neurocan
, aggrecan, phosphacan, and versican, which bind to the hyaluronan backbone of the PNN (Table 1) .