A nervous system chondroitin sulfate proteoglycan that binds to neural cell adhesion molecules and modulates neuronal adhesion and neurite outgrowth during development.


A gene on chromosome 19p12 that encodes neurocan, a chondroitin sulphate proteoglycan, which may be involved in modulating neuronal adhesion and migration as well as neurite growth during development, by binding to neural cell adhesion molecules.
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Neurocan is upregulated in injured brain and in cytokine-treated astrocytes.
Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue.
Down-regulation of neurocan expression in reactive astrocytes promotes axonal regeneration and facilitates the neurorestorative effects of bone marrow stromal cells in the ischemic rat brain.
The proteoglycans aggrecan, versican, neurocan and brevican make up one such group based on their structural and functional similarities.
The study identified evidence for association with markers in the neurocan gene (NCAN) on chromosome 19p12, and rs2501843 on chromosome 1.
A recent study [6] found genome-wide significant association between common variation in the gene neurocan (NCAN, rs1064395) and BD.
Based on FASTA sequence for 3'UTR of neurocan gene obtained from NCBI, we designed the flanking primers for rs1064395: forward 5-CATTGCCTGGTGGTCTAGAAA-3' and reverse 5-GGAGGAAGGCAAGGTGAGTT-3'.
Therefore, findings related to BP [6] and schizophrenia samples from Bosnia and Herzegovina as well as in other populations [7, 11, 12] implicate that allele A at neurocan locus ^1064395 is more frequently represented in etiopatology of bipolar disorder than of schizophrenia.
Independent studies worldwide that investigated genetic relatedness of neurocan with schizophrenia had indecisive outputs.
Other loci identified are near methylmalonic aciduria type B1/mevalonate kinase (MVK-MMAB) and UDP acetylgalactosaminyltransferase 2 (GALNT2), with high-density lipoprotein (HDL) cholesterol; near sortilin 1 (SORT1), cadherin EGF LAG seven-pass G-type receptor 2 (CELSR2) and Proline/serine-rich coiled-coil protein 1 (PSRC1) with variants primarily associated with low-density lipoprotein (LDL) cholesterol; near Tribbles homolog 1 (TRIB1), MLX interacting protein like1 (MLXIPL) and angiopoietin-like 3 (ANGPTL3), with variants primarily associated with triglycerides; and a locus encompassing several genes near neurocan (NCAN), with variants strongly associated with both triglycerides and LDL cholesterol (74,75).
It has been known from prior studies that knocking out the NCAN gene results in a developmental disorder in the brain due to the fact that the production of the neurocan protein is stopped.
They found that genetic variation in the gene neurocan (NCAN) showed a significant association with bipolar disorder in thousands of patients.