with trans-synaptic spread of infection and neurofibrillary tangles derived from intraneuronal spirochetes.
Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis
Late, delayed, or inadequate treatment can lead to serious problems, such as neuroborreliosis
or arthritis, which can be disabling and difficult to treat.
is a multisystem infectious disease that affects the cerebral WM, cranial nerves, the cauda equina, eye, joints, heart, and skin.
Differential Diagnoses for MS Vascular Susac Syndrome Central nervous system vasculitis Anti phospholipid syndrome Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy Inflammatory Systemic lupus erythematosus Neuromyelitis optica Sjogren syndrome Sarcoidosis Behcet disease Acute disseminated encephalomyelitis Infectious Lyme neuroborreliosis
Syphilis West Nile virus Progressive multifocal leukoencephalopathy Cysticercosis Human lymphotropic virus, types 1/2 HIV or herpes encephalitis Metabolic Mitochondrial diseases Wilson disease B12 deficiency Leukodystrophies Multifocal Lymphoma tumors Gliomastosis cerebri Metastases Other Spinal stenosis Central pontine myelinolysis Radiation therapy TABLE 4.
Days to weeks later, neuroborreliosis
may manifest with cranial nerve palsies, meningitis or radiculopathy.
In that study, the paper reports that 21 of 29 patients with neuroborreliosis
had positive IgG Western blot results, yielding a sensitivity of 72%.
In patients with neuroborreliosis
, CSF APO A-II concentrations were correlated with albumin concentrations regardless of cytology (38).
Key Words: CD57 lymphocytes, Lyme disease, musical hallucinations, neuroborreliosis
Repeated isolation of Borrelia burgdorfefi from cerebrospinal fluid of two patients treated for Lyme neuroborreliosis
As in the United States, other manifestations, including atrioventricular block and neuroborreliosis
, were uncommon (11).
However, he survived over 7 years once he was diagnosed with neuroborreliosis
and treated for Lyme disease and MSCIS using naturopathic and integrative medicine with a non-antibiotic-based protocol.