Because it went untreated, it was now deeply embedded in her central nervous system - she had late stage neurological Lyme Disease - neuroborreliosis
(2008) Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis
. J Neuroinflammation.
In the late period it may present as arthritis, late neuroborreliosis
, and chronic acrodermatitis (1,2,3).
Their presence can also be found in infectious CNS diseases such as neuroborreliosis
, herpes simplex encephalitis, HIV infection and subacute sclerosing panencephalitis.
The detection of specific intrathecal synthesis of antibodies is a known tool for the diagnosis of infections including herpes simplex virus, varicella zoster virus, measles, rubella, neuroborreliosis
, and human T-cell leukemia virus type 1 (6-8).
Diagnostic serology testing for herpes simplex virus, varicella-zoster virus, enteroviruses, neuroborreliosis
, and syphilis was negative in the CSF.
(LNB) can rarely present as a stroke due to cerebral vasculitis.
On the other hand, in the case of neuroborreliosis
and serious heart involvement, parenteral ceftriaxone treatment for 14-21 days is necessary (2).
Some secondary reasons have been reported: herpes zoster, temporomandibular joint dysfunction, nasopharyngeal carcinoma, petrous bone osteoma, and neuroborreliosis
Detection of Borrelia burgdorferi DNA in Urine Samples and Cerebrospinal Fluid Samples from Patients with Early and Late Lyme Neuroborreliosis
by Polymerase Chain Reaction.
Given her history of previously treated Lyme disease, her family believed she had developed Lyme neuroborreliosis
. Later, she was treated empirically for neuroborreliosis
with IV antibiotics without any improvement.
Jarocka-Karpowicz et al., "Lipid peroxidation in the pathogenesis of neuroborreliosis
," Free Radical Biology and Medicine, vol.