In summary, the results of this study revealed that treatment with GLe resulted in significant increases of cell proliferation, neuroblast
differentiation, and neuronal maturation as well as BDNF and TrkB expressions in the hippocampal DG of adult mice.
Likewise, at D14, there were no significant differences in neuroblast
density between the three groups (18,287 [+ or -] 5037 [micro][m.sup.2]; 18,528 [+ or -] 9851 [micro][m.sup.2]; and 12,476 [+ or -] 5223 [micro][m.sup.2], resp.) nor in the migration distance of DCX+ cells toward the peri-infarct area (500.5 [+ or -] 145.3 [micro]m; 592.3 [+ or -] 135.9 [micro]m; and 526.1 [+ or -] 212.5 [micro]m, resp.) (N = 4- 5).
A single tumor may contain a wide range of cellular phenotypes characteristic of this transient embryonic structure, in particular neuroblasts
, melanocytes, and nonneuronal cells such as Schwann, perineurial, or satellite cells.
Isl1-immunoreactive cell nuclei were mostly located towards the inner side of the retina where the GCL is forming but also in newly formed migratory neuroblasts
still located in the NbL.
More sophisticated and less destructive methods were slowly developed and in 1942, Carlson studied embryonic neuroblasts
of Chortophaga (Carlson 1942), perforating living cells with a microneedle to manipulate the spindle and associated chromosomes; he determined that the latter were mechanically attached to the spindle, which was a semisolid longitudinal structure, through their kinetochores from prophase through late anaphase.
New protoneurons, called neuroblasts
, proliferate by dividing at the ventricular surfaces of the brain.
This poststroke migration is very similar to the normal neuroblast
migration in the rostral migratory stream.
Monocyte chemoattractant protein-1 plays a critical role in neuroblast
migration after focal cerebral ischemia.
Dempsey, "Monocyte chemoattractant protein-1 plays a critical role in neuroblast
migration after focal cerebral ischemia," Journal of Cerebral Blood Flow and Metabolism, vol.
Wang et al., "Activated neural stem cells contribute to stroke-induced neurogenesis and neuroblast
migration toward the infarct boundary in adult rats," Journal of Cerebral Blood Flow and Metabolism, vol.
Injection of K252a to the metformin-treated group significantly reversed the amelioration of the reduction of neuroblast
differentiation induced by high-fat diet.
Chu et al., "Buyang Huanwu decoction promotes neuroblast
migration from subventricular zone via inducing angiogenesis after ischemia," Zhongguo Zhong Yao Za Zhi, vol.