In summary, the results of this study revealed that treatment with GLe resulted in significant increases of cell proliferation, neuroblast
differentiation, and neuronal maturation as well as BDNF and TrkB expressions in the hippocampal DG of adult mice.
If we could better understand the molecular migratory signals that guide neuroblasts
, we could try to redirect these cells to areas of the brain harmed by stroke or traumatic brain injury.
Anne-Catherine Bachoud-Levi from INSERM in Creteil and colleagues studied 5 patients with HD, an inherited neurodegenerative disorder, for 2 years before implanting grafts of human fetal neuroblasts
into the patients' right striata and then, after a year, their left striata.
Regulation of temporal identity transitions in Drosophila neuroblasts
Using oligomicroarray transcriptome analysis, we identified a set of 107 genes that were differentially expressed in the metastatic neuroblasts
Increasing Ang1/Tie2 expression by simvastatin treatment induces vascular stabilization and neuroblast
migration after stroke.
17-20,75-77] In contrast, the poorly differentiated, actively proliferating neoplastic neuroblasts
in the surrounding reticulin-rich/ solid areas of tumor exhibit lesser degrees of [Beta]III labeling[18,20] Moreover, neuronal tumors are GFAP negative, aside from reactive or stromal astroglial proliferations.
These effects could be mediated by impaired glucose metabolism in fetal brain during the critical period of neuroblast
proliferation (Pickard et al.
2) It contains primitive neuroblast
and mature ganglion cell component; and considered to have an intermediate malignant potential as compared to benign ganglioneuroma and malignant neuroblastoma.
Drosophila neural stem cells, The neuroblasts
(nb), Are a fantastic model of temporally and metabolically regulated cells.
In aborted human foetuses collected from endemic fluorosis area, it was found that accumulation of fluorides in brain tissue causes disruption of certain neurotransmitters and receptors in nerve cells and also increased numerical density of volume of nerves and undifferentiated neuroblasts
The condition develops from nerve cells called neuroblasts
, which are left behind from a baby's growth in the womb.