The pathogenesis of Charcot neuroarthropathy
has been attributed to multiple mechanisms, including an exaggerated overuse injury of an insensate joint subjected to microtrauma (7); the patient's abnormal sensorium prevents him or her from adopting normal protective behavior.
PubMed was searched to identify English language articles using the following search terms: neuropathic arthropathy, neuroarthropathy
, Charcot arthropathy, syringomyelia, glenohumeral joint, and shoulder.
Li et al., "Measurement of markers of osteoclast and osteoblast activity in patients with acute and chronic diabetic Charcot neuroarthropathy
," Diabetic Medicine, vol.
She had previously suffered from Charcot neuroarthropathy
of the left foot with recalcitrant ulceration on the plantar aspect and a rocker bottom deformity.
is a severe destructive form of degenerative arthritis resulting from loss of sensation in the involved joints, called as Charcot's joints or diabetic osteoarthropathy.
: an overuse injury of the shoulder in quadriplegia.
Exclusion criteria included peripheral vascular disease; amputation or ulceration within 2 years before screening; Charcot neuroarthropathy
; previous surgery to spine or lower extremity with residual pain or impaired mobility; severe arthritis causing pain upon walking; A1C >9% at screening; blood pressure > 160/90 mm Hg or uncontrolled asthma or shortness of breath in the 2 months before screening; advanced renal disease (serum creatinine >2.5 times the upper limit of normal); pregnant or nursing; and history of alcohol or drug abuse within the past 3 years.
(Charcot foot) is sometimes difficult to distinguish from DFO and can coexist.
Foot complications in diabetes (2) Peripheral neuropathy 20 - 40% of patients with diabetes Peripheral vascular disease 20 - 40% of patients with diabetes Foot ulceration 5% of patients/year Foot infection and 22 - 66% of foot ulcers osteomyelitis Amputation 0.5% of patients with diabetes/year Charcot's neuroarthropathy
0.1 - 0.4% patients with diabetes/year
of the wrist in paraplegia: A case report.
The second complication is Charcot's Neuroarthropathy
, which is characterized by erythema, edema and increased temperature, and can lead to foot deformity, ulceration and decreased function if not treated.
Armstrong, "The natural history of Charcot's neuroarthropathy
," Clinics in Podiatric Medicine and Surgery, vol.