neuritic plaque


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neu·rit·ic plaque

a spheric mass primarily composed of amyloid fibrils and interwoven neuronal processes, frequently, although not exclusively, observed in Alzheimer disease.

senile plaque

A histologic finding consisting of a core of extracellular amyloid with an amyloidogenic fragment (betaA4) derived from amyloid precursor protein, surrounded by a tangled spherical mass of argyrophilic cholinergic neuritis (axons/dendrites) seen in the grey matter (neocortex, hippocampus, amygdala, less commonly, basal ganglia and elsewhere) in the brains of older persons, but markedly increased in Alzheimer’s disease.

se·nile plaque

(sen'il plak)
A spheric mass composed primarily of amyloid fibrils and interwoven neuronal processes, frequently, although not exclusively, observed in Alzheimer disease.
Synonym(s): neuritic plaque.
References in periodicals archive ?
PART is characterized by NFT pathology in structures of the mesial temporal lobe, basal forebrain, and brainstem (Braak stages < IV) with minimal or no A[beta] or neocortical neuritic plaque pathologies.
(18) Additionally, PiB binds to both diffuse and neuritic plaques, which may affect the in vivo signal.
Bennett et al., "Correlation of amyloid PET ligand florbetapir F18 binding with A[beta] aggregation and neuritic plaque deposition in postmortem brain tissue," Alzheimer Disease and Associated Disorders, vol.
Alzheimer performed an autopsy and found abnormal deposits (neuritic plaques) and tangled bundles of nerve fibers (neurofibrillary tangles) in this woman's brain.
As early as the 1920s, the neuropathological characteristics -- particularly nerve cell loss and the appearance of abnormal cell lesions called neurofibrillary tangles and neuritic plaques -- were observed in the brains of Down's individuals over 35 years of age.
"Our observation of an elevated e4 frequency in the [pure Lewy body] and [Parkinson's dementia] groups in which the overall brain neuritic plaque burden is low suggests the possibility that ApoE isoforms also might modulate neurodegeneration by nonamyloidogenic mechanisms," they said.
"However, our observation of an elevated e4 frequency in the [pure Lewy body] and [Parkinson's dementia] groups in which the overall brain neuritic plaque burden is low suggests the possibility that ApoE isoforms also might modulate neurodegeneration by nonamyloidogenic mechanisms, they pointed out.
Pharmaceutical products company Eli Lilly and Company (NYSE:LLY) and its wholly owned subsidiary Avid Radiopharmaceuticals Inc announced on Friday the receipt of a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in Europe, recommending approval of Amyvid (Florbetapir F 18) solution for injection as a diagnostic radiopharmaceutical indicated for Positron Emission Tomography (PET) imaging of beta-amyloid neuritic plaque density.
Eli Lilly and Company (NYSE: LLY) and its wholly owned subsidiary Avid Radiopharmaceuticals Inc announced on 19 October that they have received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in Europe recommending approval of Amyvid solution for injection as a diagnostic radiopharmaceutical indicated for Positron Emission Tomography imaging of beta-amyloid neuritic plaque density in the brains of adult patients with cognitive impairment, who are being evaluated for Alzheimer's Disease and other causes of cognitive impairment.
According to the company, Amyvid (Florbetapir F-18 Injection) is indicated for Positron Emission Tomography (PET) imaging of the brain to estimate beta-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's Disease (AD) and other causes of cognitive decline.
"The results of this study suggest that combination of insulin with other diabetes medication is associated with a substantial reduction in brain neuritic plaque density consistent with the effects of both on the neurobiology of insulin," Dr.