neuraminidase inhibitor


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Related to neuraminidase inhibitor: Oseltamivir, amantadine, Tamiflu, Zanamivir

neuraminidase inhibitor

Infectious disease Any antiviral that inhibits neuraminidase, an enzyme essential for replication of influenza and other viruses. See Influenza.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

neuraminidase inhibitor

Any of a class of antiviral drugs that block neuraminidase, which helps the influenza virus to bud from cells it has infected so that it can spread to other ciliated epithelial cells of the respiratory tract. Agents in this class include oseltamivir and zanamivir.
See also: inhibitor
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Use of neuraminidase inhibitors in influenza [cited 2015 Dec 15].
Neuraminidase inhibitor sensitivity and receptor-binding specificity of Cambodian clade 1 highly pathogenic H5N1 influenza virus.
Pyrosequencing as a tool to detect molecular markers of resistance to neuraminidase inhibitors in seasonal influenza A viruses.
Peramivir A-315675 2009712047 0.13 0.66 2009712097 0.15 1.78 2009712110 0.08 0.11 2009712111 0.10 0.18 2009712113 0.09 0.19 2009712175 -- -- 2009712177 0.10 0.35 2009712190 0.06 0.63 2009712191 0.12 0.39 2009712192 0.12 0.50 2009712389 0.26 1.94 2009712390 0.07 1.03 2009712391 0.07 0.68 Control (seasonal) 0.16 0.67 Control (seasonal) 13.87 1.59 * Neuraminidase inhibitor. ([dagger]) Drug concentration needed to inhibit 50% of neuraminidase enzyme activity (determined by chemiluminescent NAI assay).
Treanor of the University of Rochester (N.Y.) was not involved in these studies but has done studies of Tamiflu and Relenza (zanamivir), the other available neuraminidase inhibitor, which is in a dry powder formulation that is inhaled.
To the Editor: In the Netherlands, the outbreak of pandemic influenza A (H1N1) 2009 led to a 100-fold increase from 2008 in prescriptions for the antiviral neuraminidase inhibitor oseltamivir (1).
Zanamivir is a neuraminidase inhibitor inhalant used in the prevention and treatment of Influenza A and Influenza B.
During the 2007-08 influenza season, an increase in the prevalence of influenza A (H1N1) viruses resistant to the neuraminidase inhibitor oseltamivir was first observed (5).
Study results have shown that these neuraminidase inhibitor drugs, which block the release of newly made virus by infected cells, work when taken within 48 hours of the onset of infection but work even better when taken as soon as possible after infection starts.
Oseltamivir (Tamiflu) is a neuraminidase inhibitor that has recently been approved for use in patients aged 13 years or more.
Identification of a human influenza type B strain with reduced sensitivity to neuraminidase inhibitor drugs.