neuraminidase


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Related to neuraminidase: sialic acid, Neuraminidase inhibitor

sialidase

 [si-al´ĭ-dās]
1. an enzyme of the hydrolase class that catalyzes the cleavage of glucosidic linkages between a sialic acid residue and a hexose or hexosamine residue at the nonreducing terminal of oligosaccharides in glycoproteins, glycolipids, and proteoglycans. Deficiency of it is an autosomal recessive trait and is seen in sialidosis and galactosialidosis.
2. the enzyme with this activity specifically cleaving sialic acid–containing gangliosides; it is deficient in mucolipidosis IV. Called also neuraminidase.

si·al·i·dase

(sī-al'i-dās),
An enzyme that catalyzes the hydrolysis of terminal acetylneuraminic residues from oligosaccharides, glycoproteins, or glycolipids; present on the surface antigen in myxoviruses; used in histochemistry to selectively remove sialomucins, as from bronchial mucous glands and the small intestine; a deficiency of this enzyme produces sialidosis.
Synonym(s): neuraminidase

neuraminidase

(no͝or′ə-mĭn′ĭ-dās′, -dāz′, nyo͝or′-)
n.
A hydrolytic enzyme that removes sialic acid from glycoproteins and is found in many cells and viruses. It occurs on the surface of influenza viruses and enables the release of newly replicated viruses from infected cells.
References in periodicals archive ?
Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice.
Assessment of pandemic and seasonal influenza A (H1N1) virus susceptibility to neuraminidase inhibitors in three enzyme activity inhibition assays.
The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor.
The neuraminidase of influenza viruses is responsible for the cleaving sialic acids from receptors, thus preventing self-aggregation and enabling the release of virus during budding from host cells (Palese et al., 1974).
Oseltamivir, the neuraminidase inhibitor, and amantadine, an M2 ion channel inhibitor, face 90% and 100% resistance respectively, in some areas.
Because [[beta].sub.1]-transferrin was present in serum but absent in drainage fluid, additional neuraminidase activity was suspected.
Neuraminidase inhibitors-the story behind the Cochrane review.
Stephen Withers and his team have spent decades studying the mechanisms by which enzymes like neuraminidase interact with sugars like sialic acid.
Subtypes of flu virus get their name from two proteins they carry on the surface: hemagglutinin and neuraminidase. There are 17 kinds of hemagglutinin and 10 different kinds of neuraminidase.
The other, neuraminidase, allows replicated viruses to break out of the cell and move on to the next target.
Sialidosis is an autosomal recessive lysosomal storage disease characterized by accumulation of sialyloligosaccharides in the blood, tissues and urine occuring as a result of mutaton of the gene coding lysosomal sialydase (neuraminidase) enzyme localized on the short arm of th 6th chromosome (1,2).
Among their perspectives are inhibiting HIV entry, helicase-primase inhibitors as a new approach to combating herpes simplex virus and varicella zoster virus, alkoxyalkyl ester pro-drugs of antiviral nucleoside phosphate and phosphonates, maribavir as a novel benzimidazole ribonucleoside for preventing and treating cytomegalovirus diseases, lethal mutagenesis as an unconventional approach to combating HIV, silencing viruses with antiviral RNAi, and neuraminidase inhibitors as anti-influenza agents.