neuraminic acid


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sialidase

 [si-al´ĭ-dās]
1. an enzyme of the hydrolase class that catalyzes the cleavage of glucosidic linkages between a sialic acid residue and a hexose or hexosamine residue at the nonreducing terminal of oligosaccharides in glycoproteins, glycolipids, and proteoglycans. Deficiency of it is an autosomal recessive trait and is seen in sialidosis and galactosialidosis.
2. the enzyme with this activity specifically cleaving sialic acid–containing gangliosides; it is deficient in mucolipidosis IV. Called also neuraminidase.

neur·a·min·ic ac·id

(nūr'ă-min'ik as'id),
An aldol product of d-mannosamine and pyruvic acid, linking the C-1 of the former to the C-3 of the latter. The N- and O-acyl derivatives of neuraminic acid are known as sialic acids and are constituents of gangliosides and of the polysaccharide components of mucoproteins and glycoproteins from many tissues, secretions, and species.
Synonym(s): prehemataminic acid

neuraminic acid

/neu·ra·min·ic ac·id/ (noor″ah-min´ik) a 9-carbon amino sugar whose N- acyl derivatives are the sialic acids.

neuraminic acid

[noor′ah-min′ik]
a nine-carbon amino acid formed from mannosamine and pyruvate. See also sialidase.

neu·ra·min·ic ac·id

(nūr'ă-min'ik as'id)
An aldol product of d-mannosamine and pyruvic acid. The N- and O-acyl derivatives of neuraminic acid are known as sialic acids and are constituents of gangliosides and of the polysaccharide components of muco- and glycoproteins from many tissues and secretions.

neuraminic acid

a nine-carbon sugar; parent of a family of amino sugars containing nine or more carbon atoms (the sialic acids or nonulosaminic acids).
References in periodicals archive ?
Our basic knowledge on the occurrence and complicated structure of neuraminic acid itself and the various sialic acid forms and the numerous metabolic reactions and genes involved in the synthesis, modification, transfer, and breakdown, and principal (patho-physiological) functions of Sia was acquired since the 1940s.
1986) A naturally occurring deaminated neuraminic acid, 3-deoxy-D-galacto-nonulosonic acid (KDN).
Blood was collected by heart puncture, serum separated, and used to estimate serum sialic acid by thiobarbituric acid assay (Skoza and Mohos 1976) with N-acetyl neuraminic acid as standard.
A naturally occurring deaminated neuraminic acid, 3-deoxy-D-glycero-D-galacto-nonulosonic acid (KDN).
Rapid analysis of O-acetylated neuraminic acids by matrix assisted laser desorption/ionization time-of-flight mass spectrometry.
N-acetyl neuraminic acid is an important immunomodulating carbohydrate that plays a very important role in the proper development of the lining of the small intestine from the standpoint of both its digestive and immune functions.
Neuraminic acid, N-acetylaspartic acid, and the N-acetyl groups in glycoproteins in urine from healthy controls are known to contribute to the resonances in this area (10).
Sialic acids are derived from neuraminic acid whose main derivative is N-acetylneuraminic acid, which is generally used as a synonym for sialic acid (Ledeen and Yu 1976).
N-acetyl neuraminic acid and papain were obtained from Sisco Research Laboratory (Bombay).
Sialic acid content was determined from the standard graph plotted using n-acetyl neuraminic acid.
2]-transferrin ([beta]2Tr) r-fraction, or asialotransferrin, is a brain-specific variant of transferrin that lacks neuraminic acid.
The spectrum of free neuraminic acid storage disease in childhood: clinical, morphological and biochemical observations in three non-Finnish patients.