neuraminic acid


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sialidase

 [si-al´ĭ-dās]
1. an enzyme of the hydrolase class that catalyzes the cleavage of glucosidic linkages between a sialic acid residue and a hexose or hexosamine residue at the nonreducing terminal of oligosaccharides in glycoproteins, glycolipids, and proteoglycans. Deficiency of it is an autosomal recessive trait and is seen in sialidosis and galactosialidosis.
2. the enzyme with this activity specifically cleaving sialic acid–containing gangliosides; it is deficient in mucolipidosis IV. Called also neuraminidase.

neur·a·min·ic ac·id

(nūr'ă-min'ik as'id),
An aldol product of d-mannosamine and pyruvic acid, linking the C-1 of the former to the C-3 of the latter. The N- and O-acyl derivatives of neuraminic acid are known as sialic acids and are constituents of gangliosides and of the polysaccharide components of mucoproteins and glycoproteins from many tissues, secretions, and species.
Synonym(s): prehemataminic acid

neu·ra·min·ic ac·id

(nūr'ă-min'ik as'id)
An aldol product of d-mannosamine and pyruvic acid. The N- and O-acyl derivatives of neuraminic acid are known as sialic acids and are constituents of gangliosides and of the polysaccharide components of muco- and glycoproteins from many tissues and secretions.
References in periodicals archive ?
From over 30 acetylated derivatives of neuraminic acid, N-acetylneuraminic acid (referred to as sialic acid) is the most common in humans.
Their chemistry varies; the Sia family, representing about 50 members, are all derivatives of the 5-amino 2- keto-3-deoxy nononic acid, the "neuraminic acid" (Fig.
N-Acetyl neuraminic acid was purchased from Sisco Research Laboratory (Mumbai, India).
In SP-HUS, bacterial neuraminidase is thought to cleave N-acetyl neuraminic acid from the surface of red blood cells, platelets, and endothelium, exposing the Thomsen-Friedenreich (T) cryptantigen.
Sialic acid, which is a derivative of acetyl neuraminic acid, attached to non-reducing residues of carbohydrate chain of glycoproteins and glycolipids is found to be elevated in alcohol abuse (8).
HN also acts as an enzyme (NA, neuraminidase or sialidase) that removes sialic acid (neuraminic acid) moieties from viral progeny to prevent self-aggregation, favoring the release of virions from the cell.
It contains a unique, polymerized glyconutrient ingredient that incorporates all eight essential monosaccharides (glucose, xylose, fucose, N-acetyl galactosmine, mannose, N-Acetyl glucosamine, N-acetyl neuraminic acid and galactose) in a single, non-branched polysaccharide chain.
meningitidis isolates in Canada bore an [alpha] 2-9 N-acetyl neuraminic acid (serogroup C) capsule, but recent epidemics of meningococcal disease, particularly in Africa, have been associated with ST11 meningococci bearing the W135 capsule.
A rapid and sensitive procedure for determination of 5-N-acetyl neuraminic acid in lipopolysaccharides of Haemophilus influenzae: a survey of 24 non-typeable H.
Supplements that may be useful in achieving these ends include N-acetyl glucosamine, N-acetyl neuraminic acid (sialic acid), D-mannose, L-glutamine, L-glutamic acid HC1, inulin, quercitin, methylsulfonylmethane (MSM), Manapol[R], and digestive enzyme formulations, with, or without, hydrochloric acid.
Dr Sweet said the new generation of drugs was designed to work against all kinds of flu viruses by targeting a protein called N-acetyl neuraminic acid.
Hemolysis depends on the sialic acid-binding activity of limulin, because sialylated glycoconjugates, such as fetuin, and the sialic acids N-acetyl neuraminic acid and colominic acid inhibit hemolysis.