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1. an enzyme of the hydrolase class that catalyzes the cleavage of glucosidic linkages between a sialic acid residue and a hexose or hexosamine residue at the nonreducing terminal of oligosaccharides in glycoproteins, glycolipids, and proteoglycans. Deficiency of it is an autosomal recessive trait and is seen in sialidosis and galactosialidosis.
2. the enzyme with this activity specifically cleaving sialic acid–containing gangliosides; it is deficient in mucolipidosis IV. Called also neuraminidase.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
neur·a·min·ic ac·id(nūr'ă-min'ik as'id),
An aldol product of d-mannosamine and pyruvic acid, linking the C-1 of the former to the C-3 of the latter. The N- and O-acyl derivatives of neuraminic acid are known as sialic acids and are constituents of gangliosides and of the polysaccharide components of mucoproteins and glycoproteins from many tissues, secretions, and species.
Synonym(s): prehemataminic acid
Farlex Partner Medical Dictionary © Farlex 2012
neu·ra·min·ic ac·id(nūr'ă-min'ik as'id)
An aldol product of d-mannosamine and pyruvic acid. The N- and O-acyl derivatives of neuraminic acid are known as sialic acids and are constituents of gangliosides and of the polysaccharide components of muco- and glycoproteins from many tissues and secretions.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012