neural tube defects


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neural tube defects

See SPINA BIFIDA and ANENCEPHALY. See also FOLIC ACID.

Neural tube defects

A group of birth defects that affect the backbone and sometimes the spinal chord.
Mentioned in: Birth Defects
References in periodicals archive ?
The two regulators said they were assessing evidence of the connection between dolutegravir and birth defects, adding that it should not be prescribed to women seeking to become pregnant.The move made mid last may followed preliminary data from a study in Botswana which found four cases of neural tube defects such as spina bifida, in babies born to mothers who became pregnant while taking the drug.
The release states that to date, more than 2 500 women who began taking DTG after the time of conception have not reported any cases of neural tube defects and that there has been no infant born with a neural tube defect from women who started DTG after their first three months of pregnancy.
He said: "The mandatory fortification of flour to prevent spina bifida and neural tube defects is an important and cost effective public health measure.
Many clinical studies have found that maternal supplementation with vitamins including folic acid, before conception and during the first trimester of pregnancy, significantly reduces the risk of neural tube defects.(5-12) It appears that folic acid is the most important of these vitamins.
Updated estimates of neural tube defects prevented by mandatory folic Acid fortification--United States, 1995-2011.
A (https://www.nih.gov/news-events/news-releases/low-levels-vitamin-b12-may-increase-risk-neural-tube-defects) 2009 study on the risks of vitamin B12 deficiency conducted by researchers at the National Institutes of Health, Trinity College, Dublin, and Health Research Board of Ireland, found that women who do not get enough vitamin B12 during early pregnancy are five times more likely to face the risk of having a child with a neural tube defect, a class of birth defect, as compared to those women who have a higher intake and level of the vitamin in their bodies.
Inositol and Neural Tube Defects: Experimental Models
Perturbations of these interconnected processes result in neural tube defects (NTDs), which are the most common congenital malformation affecting this system and are associated with significant complications.
Folic acid, a synthetic form of folate, is a B vitamin that when taken by a pregnant woman may help prevent neural tube defects, which are birth defects affecting the brain, spine, and spinal cord.
When most physicians and patients hear about folic acid, they automatically think about its role in preventing spina bifida and other neural tube defects. But there are now more than 20 years of data that point toward a larger role for folic acid in preventing common, and in some cases devastating, congenital heart defects.
C677T polymorphism of the methylentetrahydrofolate reductase gene in mothers of children affected with neural tube defects.
The Centers for Disease Control and Prevention's recent report updating the estimated number of neural tube defects prevented by folic acid fortification of enriched cereal grain products clearly shows the huge impact of fortification: From 1999 through 2011, fortification prevented neural tube defects in about 1,300 births a year in the United States (MMWR 2015;64:1-5).