neural

(redirected from neural substrates)
Also found in: Dictionary, Thesaurus, Encyclopedia.

neural

 [noor´al]
pertaining to a nerve or to the nerves; called also nervous.
neural tube defect a congenital defect in closure of the bony encasement of the spinal cord or of the skull. The most severe defects are a fissure along the entire length of the spinal column that leaves the meninges and spinal cord exposed (rachischisis), or herniation through the skull of a saclike structure containing brain tissue and meninges (encephalocele). anencephaly is a major defect in which the brain is absent and there is only an exposed vascular mass with no bony covering.

Classification and nomenclature of spinal column defects are based on the extent to which the meninges and spinal cord are involved. spina bifida refers to abnormal closure with or without visible protrusion of the meninges and spinal cord through the cleft in the spinal column. If there is no visible protrusion, the condition is called spina bifida occulta. An external protrusion consisting of a saclike structure is called spina bifida cystica. Two subtypes of spina bifida cystica are meningocele, which involves the meninges surrounded by spinal fluid, and myelomeningocele (or meningomyelocele), in which the sac contains meninges, spinal fluid, and a portion of the spinal cord with its nerves.

Developmental defects of the neural tube tend to run in families and are believed by most authorities to occur during early development of the embryo. Prenatal detection of some major open neural tube defects is possible through ultrasonic scanning of the uterus and laboratory evaluation of the amniotic fluid. In the presence of anencephaly and meningomyelocele there are elevated concentrations of alpha-fetoprotein in the amniotic fluid.

Genetic predisposition to neural tube defects is inheritable; thus family history is significant in predicting the risk of recurrence. For example, a couple who has had one child with such a defect has a one in twenty (5 per cent) probability of having a second child with the disorder. The risk is doubled to one in ten (10 per cent) if two of their children are so affected. Siblings of an affected child who are themselves normal are at greater than average risk of producing a child with a similar problem.
Treatment. Immediate care of the neonate with a neural tube defect includes prevention of infection and assessment of neurological involvement. Later, an orthopedic assessment is done to identify problems related to locomotion. Corrective procedures such as casting, bracing, and traction are indicated if there is hope for some functioning of the lower extremities. Associated anomalies of the hip, knee, and foot may require correction by orthopedic surgery.

Meningoceles usually are repaired to prevent infection, especially if there is danger of rupture of the sac. Most authorities recommend closure within the first 24 to 48 hours after birth. However, authorities do not agree on whether an attempt should be made to perform skin closure over a myelomeningocele. If hydrocephalus develops, the treatment of choice is a ventriculoperitoneal shunt or some other procedure to drain spinal fluid and decompress the fluid-filled ventricles.

Bowel and bladder dysfunction usually occur as a result of myelomeningocele. Management of neurogenic bladder and incontinence includes preventing urinary stasis and infection and providing some means for collecting urine. Fecal incontinence may be amenable to bowel training and modification of the diet. In some children a colostomy is the most desirable way to handle the problem.
Patient Care. Immediate concerns in the care of the newborn with a neural tube defect center on protection of the fragile sac from trauma and infection, observation for complications, and support and guidance for parents and family members. Positioning before and after surgery is critical. Preoperatively, the goal is to minimize tension on and trauma to the sac. The baby may be placed in a prone position with head slightly lower than body to reduce spinal fluid pressure in the sac. The hips are slightly flexed to relieve tension on the spine. After surgery, it may be desirable to elevate the head because of increased intracranial pressure and impending hydrocephalus. Many surgeons allow a side-lying position postoperatively because of diapering and feeding problems associated with the prone position. The variety of allowable positions permits frequent position changes to avoid pressure sores. As soon as the operative site is sufficiently healed, the baby can be held for feeding and receiving the body contact every neonate needs. If a baby with inoperable myelomeningocele cannot be held and cuddled, stroking, fondling, and other comfort measures can be used to meet the need for tactile stimulation.

Long-term care will depend on the specific orthopedic, urologic, and neurologic problems each child has. Patients will require continued guidance and support. Comprehensive care for the patient and family can only be provided by a coordinated team of health care providers, including physicians, nurses, physical therapists, rehabilitation specialists, and social workers. The familial tendency toward neural tube defects demands that genetic counseling be available to the family.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

neu·ral

(nū'răl), Avoid forming incorrect compounds, such as neuroformamina instead of neural foramina.
1. Relating to any structure composed of nerve cells or their processes, or that on further development will evolve into nerve cells.
2. Referring to the dorsal side of the vertebral bodies or their precursors, where the spinal cord is located, as opposed to hemal (2).
[G. neuron, nerve]
Farlex Partner Medical Dictionary © Farlex 2012

neural

(no͝or′əl, nyo͝or′-)
adj.
1. Of or relating to a nerve or the nervous system.
2. Of, relating to, or located on the same side of the body as the spinal cord; dorsal.

neu′ral·ly adv.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

neural

adjective Referring to neurons.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

neu·ral

(nūr'ăl)
1. Relating to any structure composed of nerve cells or their processes, or that on further development will evolve into nerve cells.
2. Referring to the dorsal side of the vertebral bodies or their precursors, where the spinal cord is located, as opposed to hemal (2).
[G. neuron, nerve]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

neural

relating to nerves or to the nervous system.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Concurrently with the behavioral improvement, changes in the neural substrates sustaining verb naming were observed in both participants, with distinctive activation patterns observed posttherapy, including areas related to the nature of POEM therapy.
In sum, using multifeature MMN paradigms and the variants, researchers have demonstrated that the neural substrates underlying conscious musical experience may involve the following three stages: (1) the encoding and temporal integration of each sound characterized by its specific acoustic and perceptual features (e.g., pitch, duration, and timbre) into brief neural traces, (2) the simultaneous maintenance and integration of the neural traces for acoustic features leading possibly to the memorization of musical motifs, and (3) the modulation of sound perception by the memory of the previous sounds (for a review, see [58]).
Future research should seek to investigate if face- and expert-specific N170s rely on the same neural substrates.
First, basic emotions have different underlying neural substrates. In other words, different emotions operate on different neural pathways.
EP must come to terms with this neuropsychological evidence (and with the similar evidence for neural substrates for other non-adaptive psychological phenomena, e.g., musical ability).
They discuss the history of the emergence of the Big Five model and its limitations and related models; the efforts of Hans Eysenck, Jeffrey Gray, and Robert Cloninger to describe personality traits and the underlying neural substrates of personality differences, including differences from the authorsAE work; the genetic foundations and epigenetic controls of personality; the use of brain imaging to study emotion; ideas about self-concept from the perspective of neuroscience; and their Affective Neuroscience Personality Scales personality assessment to evaluate psychopathology.
Milliken, "Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct," Science, vol.
Thompson-Schill and colleagues [127], for example, reported that patients with left inferior prefrontal lesions implicating neural substrates in Brodmann's BA 44, but not those with prefrontal lesions excluding these neural substrates or patients with right hemisphere damage, show very poor performance on noun selection tasks with high competing demands, arguing for a selection among competitors deficit.
Winstein described the study as "the linking of motor neuroscience to behavioral movement science to better understand the neural substrates that mediate motor learning through optimal practice structures.
"By gauging properly defined actions of either overcoming fear or succumbing to it in an acute controllable fearful situation, one can render certain neural substrates of courage amenable to investigation in a brain research laboratory setting," explains senior study author, Dr.
Among the eight topics are normal and pathological aging, comparing different cognitive rate models of human aging, behavioral tasks and neural substrates in mouse models, hormone influences on brain aging and age-related cognitive decline, and time deficits in aging and neuropathology.