The protein, called
netrin, strengthens connections between brain cells.
The DCC gene is a receptor protein for
netrin, which is involved in axonal migration of neurons across the body's midline during the developmental stage (16).
Several genes (potein kinase, CGMP-dependent, type I [PRKG1], rap guanine nucleotide exchange factor 2 [RAPGEF2], RAB17, member RAS oncogene family [RAB17], neural EGFL like 1 [NELL1], DCC
netrin 1 receptor [DCC], NCK adaptor protein 2 [NCK2], ghrelin and obestatin prepropeptide [GHRL], adhesion G protein-coupled receptor B3 [ADGRB3], and NTRK2) were identified that trigger dendrite development [29-31].
Netrin 1 which resembles the extracellular matrix protein laminin, guide the axonal conduction.
Thus, this review is intended to discuss the role on
Netrin as a novel biomarker so as to detect earlier diabetic complications or predictor of diabetic risks and as a possible therapeutic goal so as to propose safe and effective antidiabetic agents.
It is a transmembrane protein that stops cell growth in absence of
Netrin and its ligand.
(2000)
Netrin 1 acts as an attractive or as a repulsive cue for distinct migrating neurons during the development of the cerebellar system.
Third, two classes of molecular inhibitors to growth are present in the lesioned CNS to actively block axonal growth: inhibitory extracellular matrix proteins, including chondroitin sulfate proteoglycans, and inhibitory proteins present on adult myelin, including Nogo, myelin-associated glycoprotein, oligodendrocyte-myelin glycoprotein,
netrin, semaphorins, Wnt proteins, and others [64-66].
Soluble adenylyl cyclase responds to both extracellular (tumor necrosis factor,
netrin, nerve growth factor) and intracellular (bicarbonate, pH, calcium) signals.
Expression of the
netrin receptor UNC-5 in lamprey brain: modulation by spinal cord transection.
He says that the latest set of findings suggest that integrin helps the anchor cell orient itself toward the basement membranes, and that it also directs
netrin to build the puncta in the proper place to ease an opening through.
