nested variant of urothelial carcinoma

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nested variant of urothelial carcinoma

A rare (less than 0.3% of invasive bladder tumours), deceptively bland yet clinically aggressive urothelial carcinoma, which affects older people, especially males.
 
Clinical findings
Haematuria (usually macroscopic), dysuria, frequency, nocturia. Despite NVUCs’ low-grade histology, they are bad actors which, given the typical delay in diagnosis, contributes to their more advanced local stage compared to conventional high-grade urothelial carcinoma.

Management
The optimal treatment for NVUCs is uncertain given its rarity—radical resection is recommended; chemo- and radiotherapy are completely ineffective.
 
Prognosis
Most patients die within 3 years.
References in periodicals archive ?
The nests of nested urothelial carcinoma are closely packed, with irregular borders, in contrast to VBNs, which are closely packed at the centre of the focus and may be scattered at the peripheral sides.
Also useful is the presence of edematous inflammatory stroma in NA, in contrast to the desmoplastic/myxoid stroma commonly seen in nested urothelial carcinoma.