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Hyperplasia of the cells of the islets of Langerhans.
[nesidioblast + G. -osis, tumor]
Farlex Partner Medical Dictionary © Farlex 2012
nesidioblastosis(1) A term first used in 1938 by Laidlaw for the neodifferentiation of islets of Langerhans from pancreatic ductal epithelium, which is clinically characterised by severe recurrent hypoglycemia and inappropriate elevation of serum insulin, C-peptide, and proinsulin. It was later renamed persistent hyperinsulinemic hypoglycemia of infancy (PHHI; some authors prefer congenital hyperinsulinism—CH). It is the most common cause of hyperinsulinism in neonates and, if untreated, can lead to hypoglycaemic brain damage or death. Once regarded as exclusive to infants and children, it may rarely occur in adults. PHHI/CH responds poorly if at all to medical management, mandating subtotal pancreatectomy.
(2) Acquired hyperinsulinism in adults caused by beta cell hyperplasia post-GI surgery.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Diffuse hyperplasia of the beta cells in the islets of Langerhans of the pancreas. It is a rare cause of hypoglycemia.
Medical Dictionary, © 2009 Farlex and Partners