Diabetes in a nonpancreatectomized child with nesidioblastosis
. Diabetes Care 2004;27:626-627.
(13) performed angiographic anesthesia for a case of nesidioblastosis
with insulinoma and reported that an infusion of propofol and remifentanil did not impair hemodynamic stability in their study.
Single case reports mediastinal teratomas with either increased exocrine pancreatic activity  or associated with aberrant islet differentiation or nesidioblastosis
Perren et al., "Persistent hyperinsulinemic hypoglycemia in 15 adults with diffuse nesidioblastosis
," The American Journal of Surgical Pathology, vol.
(8) Similar to multiple endocrine neoplasia type 1 (MEN1) syndrome, patients with VHL disease can be associated with precursor lesions including ductuloinsular complexes (nesidioblastosis
), islet dysplasia (referring to normal-sized or slightly enlarged islets <0.5 mm that contain neuroendocrine cells showing loss of the normal spatial and quantitative arrangement of the normal [alpha], [beta], [delta], and PP cell types), pancreatic micro-adenomatosis (when islet dysplasia is between 0.5-5 mm, it is termed microadenoma-, multiple microadenomas are termed microadenomatosis), and peliosis of the nontumorous islets (17) (Figure 2, A and B).
A safety concern that has been gaining attention is the late development of post-prandial hypoglycemia and nesidioblastosis
after gastric bypass.
HI was first described in 1954 by MacQuarrie (1) as "idiopathic hypoglycemia of infancy." HI has subsequently been referred to by many names, including leucine-sensitive hypoglycemia, islet dysregulation syndrome, persistent hyperinsulinemic hypoglycemia of infancy, and nesidioblastosis
es una complicacion metabolica que puede amenazar la vida, y aunque no se presenta frecuentemente, hay que sospecharla cuando hay neuroglicopenia.
When my small patient, in whom nesidioblastosis
had been newly diagnosed, was returned to my care, little was needed but to follow along with the suggested treatment of diazoxide.
The search terms were "hyperinsulinism" or "CHI" or "nesidioblastosis
" or "hypoglycemia" or "persistent hyperinsulinemic hypoglycemia of infancy" or "hyperinsulinemic hypoglycemia of infancy" or "HI" or "hyperinsulinaemic" or "hyperinsulinemic" and "Turkey" or "Turkish".
(19) The background pancreas characteristically lacks nesidioblastosis
or hyperplasia of the islets of Langerhans, in contrast with neuroendocrine tumors associated with the multiple endocrine neoplasia syndromes.
Pancreatic growth and function following surgical treatment of nesidioblastosis