nerve growth factor

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nerve growth fac·tor (NGF),

a protein (MW about 27,000) that controls the development of sympathetic postganglionic neurons and possibly also sensory (dorsal root) ganglion cells in mammals; similar factors have been isolated from the venom of several species of snakes; it has been isolated from the submaxillary glands of male mice, and when it is injected into newborn animals, sympathetic ganglia become hyperplastic and hypertrophic; stimulates synthesis of nucleic acids and protein.
Farlex Partner Medical Dictionary © Farlex 2012

nerve growth factor

n. Abbr. NGF
A protein that stimulates the growth of sympathetic and sensory nerve cells.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

nerve growth fac·tor

(NGF) (nĕrv grōth fak'tŏr)
A protein secreted by the neuron's target, critical for the survival and maintenance of sympathetic and sensory neurons. The movement of NGF from axon tip to soma is thought to be involved in the long-distance signaling of neurons; binds at least two receptors, which are capable of responding to this growth factor, TrkA (pronounced "Track A") and the LNGFR (for "low affinity nerve growth factor receptor") on the surface of cells.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

nerve growth factor

A peptide substance that stimulates growth and differentiation of NEURONES in the sympathetic and sensory nervous system. Nerve growth factor has been found effective in promoting the healing of corneal ulcers due to loss of the sensory innervation of the cornea. Corneal transparency has been restored by this means.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

nerve growth factor (NGF)

a protein required for the maintenance of some types of neurone such as sympathetic and sensory neurones. It is produced by some nerve cell target tissues, e.g. smooth muscle. NGF also stimulates the production of nerve cell processes from developing neurones.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

Nerve growth factor

A protein resembling insulin that affects growth and maintenance of nerve cells
Mentioned in: Numbness and Tingling
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Oral carcinoma with perineural invasion has higher nerve growth factor expression and worse prognosis.
Reductions of acetylcholine release and nerve growth factor expression are correlated with memory impairment induced by interleukin-1beta administrations: effects of omega-3 fatty acid EPA treatment.
Nerve growth factor production accelerators and compositions for preventing or treating neuronal degeneration.
Transection of the olfactory nerves induces expression of nerve growth factor receptor in mouse olfactory epithelium.
Effects of topically administered nerve growth factor on axonal regeneration in peripheral nerve autografts implanted in the spinal cord of rats.
Tanezumab is a humanized monoclonal antibody that is part of an investigational class of non-opioid pain medications known as nerve growth factor inhibitors.
Oxervate is based on cenegermin-bkbj, a novel recombinant human nerve growth factor (rhNGF) that is structurally identical to the nerve growth factor protein that is made in the human body, including in the ocular tissues.
Background: Recent research indicates that nerve growth factor (NGF) promotes cardiac repair following myocardial infarction by promoting angiogenesis and cardiomyocyte survival.
The unique proNGF Rapid ELISA kit specific for the important, biologically active isomeric form of Nerve Growth Factor, has recently been used to explore the emerging, central role this growth factor has in prostate, breast and bladder cancers, added the company's COO Dr Foster.
The likely suspect is Nerve Growth Factor (NGF), a molecule responsible for generating signals that maintain healthy cholinergic neurons - a subset of brain cells that are particularly sensitive to AD - throughout a person's lifetime.
The compound, a nerve growth factor, is associated with f preserving the brain's ability to grow and change through the years in response to new challenges, and to resist depression, memory loss, brain shrinkage, and other problems, esspecially in older adults.
LONDON -- An investigational nerve growth factor inhibitor, fulranumab, showed promising efficacy and safety as a pain reliever for patients with hip or knee osteoarthritis in 12-week results from a phase II study of 466 patients.