of our first case showed signs of leprosy and electrophysiological tests in both, suggested a sensory-motor, axonal polyneuro-pathy with secondary demyelination.
Giant axons found in nerve biopsy
, and gene test can help in making the diagnosis.
Caption: Figure 3: Sural nerve biopsy
of a mixed myelin-axonal damage CMT1A patient showing features of typical onion bulb lesions and regeneration clusters (black arrow).
Relapse will be defined by the presence of new signs and symptoms or new finding of AFBs in skin or nerve biopsy
. Relapse rates after MDT are typically low (< 1%), but may be higher, depending on the treatment regimen, duration of follow up and if it was determined by physical examination, skin smear or biopsy.
In patients with CIP the pain stimulus is not properly transmitted to the central nervous system due to an alteration of the structure or function of the sensory pathways that becomes evident as abnormalities on NCS and nerve biopsy
Axonal neuropathy was diagnosed by electrophysiology and nerve biopsy
findings with active axonal degeneration, mild fiber loss and without inflammation.
Indications and usefulness of nerve biopsy
. Arch Neurol.
As already explained above, the peripheral nerve biopsy
is completely normal.
Coverage encompasses MRI-targeted fascicular nerve biopsy
, scientific reports on new molecular genetic insights, and autonomic disorders, with the bulk of the chapters consisting of illustrated case studies on the evaluation and management of the most common peripheral nerve disorders, with discussion of diagnosis, clinical features, imaging, histopathology, and other aspects.
A sural nerve biopsy
can distinguish inflammatory and genetic neuropathies.
The data were further supported by sural nerve biopsy
and cutaneous nerve biopsy
studies (Kuo et al.
Chemically, they consist of abnormally branched glycogen with small amounts of protein, sulfate, and phosphate groups. The diagnosis can be made by light microscopic evaluation of a sural nerve biopsy
. It has been suggested, however, that the diagnosis can be established by a less invasive skin biopsy revealing similar inclusions in myoepithelial cells of apocrine glands.