For now, efforts to prevent acute renal failure should include avoidance or reduction of conditions and agents that increase the risk, including hypotension, nephrotoxins
, and renal ischemia.
It is likely that in this case underlying renal impairment and treatment with two nephrotoxins
all contributed to the development of severe acute renal failure.
were aminoglycosides, vancomycin and nonsteroidal anti-inflammatory drugs.
4 The known causes of ARF are similar to non-HIV patients, with the most common being acute tubular necrosis (ATN) secondary to sepsis, hypotension, dehydration and nephrotoxins
Changes in kim-1 outperformed changes in SCr, BUN or N-acetyl-[beta]-D-glucosaminidase for detecting kidney injury due to multiple nephrotoxins
b) Nephrotoxicity and electrolyte abnormalities may be prevented by avoiding amphotericin B in patients with renal impairment, by prehydration, by avoiding concurrent use of other nephrotoxins
(non-steroidal anti-inflammatory agents (NSIADs), aminoglycosides including streptomycin) and by routine administration of potassium and magnesium supplements.
Avoidance of common nephrotoxins
such as nonsteroidal anti-inflammatory drugs and contrast agents may also be particularly germane for individuals in an age group with high use of over-the-counter analgesics for musculoskeletal complaints and who are subject to increased radiographic testing.
Risk factors and predictors for CKD progression established to date include ethnicity, type of renal disease, and modifiable risk factors, such as blood pressure, proteinuria, smoking, dyslipidemia, obesity, and anemia, as well as exposure to nephrotoxins
and baseline kidney function (2, 3).
The ILSI Genomics Project is focusing on three categories of toxicants: in vivo hepatotoxins, in vivo nephrotoxins
, and in vitro genotoxins.
Investigations into the biochemical effects of region-specific nephrotoxins
Urinary biomarkers to detect significant effects of environmental and occupational exposure to nephrotoxins