auriculata could be due to its antioxidant property and free-radical-scavenging property and thus this plant could play a promising role in the treatment of acute renal failure induced by nephrotoxins
like cisplatin and gentamicin.
Key goals include maintenance of renal blood flow and oxygenation, avoidance of nephrotoxins
and toxic metabolites, and maintenance of high urine flows in an effort to prevent tubular lumen obstruction, said Dr.
The most common of these are infections such as pyelonephritis and acute tubular necrosis caused by ischemia and nephrotoxins
(NSAIDs, aminoglycosides, X-ray contrast media).
c) Causes of AKI were ischemia (24%), cardiac surgery (13%), nephrotoxins
(6%), sepsis (44%), volume depletion (3%), pancreatitis (1%), hepatorenal syndrome (1%), catastrophic antiphosolipid syndrome (1%), and multifactorial (7%).
The aminoglycosides are potent nephrotoxins
, in part because of the high concentrations they attain in the proximal tubular cells (PTCs)--up to 10% of the total parenteral dose may be concentrated in these cells.
Ischemic ATN is caused by prolonged pre-renal azotemia or by sepsis and toxic ATN is caused by direct tubular damage by nephrotoxins
, such as aminoglycosides or radio contrast agents (Cheung et al.
There may be precipitating factors, such as dehydration, hypercalcemia, hyperurice mia, infections, or exposure to contrast media, nonsteroidal anti-inflammatory drugs, nephrotoxins
, or loop diuretics, such as furosemide.
Among individuals with limited kidney function and among many elderly people whose kidney function declines as they age, exposure to cadmium and other nephrotoxins
, even at very low levels, can prove extremely dangerous.
Damage may occur in the glomerulus (post-streptococcal infection, systemic lupus erythematosus, Good-pasture's syndrome, and bacterial endocarditis), renal vessels (inflammation or obstruction), nephrons (acute pyelonephritis, allergic reactions, hypercalcemia, uric acid nephropathy, myeloma of the kidney), and/or renal tubules (postischemia and nephrotoxins
-- antibiotics, heme pigments, and radiocontrast media).
such as the nonsteroidal anti-inflammatory drugs (NSAIDs) and aminoglycosides should be used with caution throughout the pregnancy.