For now, efforts to prevent acute renal failure should include avoidance or reduction of conditions and agents that increase the risk, including hypotension, nephrotoxins
, and renal ischemia.
It is likely that in this case underlying renal impairment and treatment with two nephrotoxins
all contributed to the development of severe acute renal failure.
auriculata could be due to its antioxidant property and free-radical-scavenging property and thus this plant could play a promising role in the treatment of acute renal failure induced by nephrotoxins
like cisplatin and gentamicin.
Over thirty pharmaceutical companies participate in this effort that focuses on three categories of toxicants, hepatotoxins, nephrotoxins
, and genotoxins.
Such nephroprotective indications include prevention of acute renal failure after renal transplantation; prevention of acute renal failure after high-risk surgical procedures; and prevention of acute renal failure after administration of nephrotoxins
such as cyclosporin, cisplatin, aminoglycoside antibiotics, amphotericin B and iodinated radio-contrast agents.
in animal studies) biomarker of nephrotoxic tubular injury on the basis of carefully conducted rodent studies involving a range of nephrotoxins
4 The known causes of ARF are similar to non-HIV patients, with the most common being acute tubular necrosis (ATN) secondary to sepsis, hypotension, dehydration and nephrotoxins
Changes in kim-1 outperformed changes in SCr, BUN or N-acetyl-[beta]-D-glucosaminidase for detecting kidney injury due to multiple nephrotoxins
b) Nephrotoxicity and electrolyte abnormalities may be prevented by avoiding amphotericin B in patients with renal impairment, by prehydration, by avoiding concurrent use of other nephrotoxins
(non-steroidal anti-inflammatory agents (NSIADs), aminoglycosides including streptomycin) and by routine administration of potassium and magnesium supplements.
Avoidance of common nephrotoxins
such as nonsteroidal anti-inflammatory drugs and contrast agents may also be particularly germane for individuals in an age group with high use of over-the-counter analgesics for musculoskeletal complaints and who are subject to increased radiographic testing.
Risk factors and predictors for CKD progression established to date include ethnicity, type of renal disease, and modifiable risk factors, such as blood pressure, proteinuria, smoking, dyslipidemia, obesity, and anemia, as well as exposure to nephrotoxins
and baseline kidney function (2, 3).
The ILSI Genomics Project is focusing on three categories of toxicants: in vivo hepatotoxins, in vivo nephrotoxins
, and in vitro genotoxins.