The following adverse reactions have been reported: nephrotoxicity
, ototoxicity, myelosuppression, leukopenia, thrombocytopenia, anemia, fever, infection, nausea, and vomiting.
Given the multiple reports regarding the TDF nephrotoxicity
with some countries already switching to TAF, we decided to investigate any toxic effects of TDF in our cohort of Omani patients.
Nephroprotective effect of catechin on gentamicin-induced experimental nephrotoxicity
. Clinical and experimental nephrology 2015; 19(2): 178-84.Zhou P, Yu JF, Zhao CG, Sui FX, Teng X, Wu YB.
is another major toxicity caused by cisplatin treatment.
Can pharmacokinetic dosing decrease nephrotoxicity
associated with aminoglycoside therapy?
Pycnogenol prevents potassium dichromate K2Cr2O7-induced oxidative damage and nephrotoxicity
Thus, the widespread use of CDDP in the treatment of various solid tumors in these animals, as well as in humans, is associated with a problematic issue of nephrotoxicity
(Knapp et al., 1987, 1988).
L-methionine attenuates gentamicin nephrotoxicity
in male Wistar rat: pathological and biochemical findings.
Cisplatin is a chemotherapeutic used for treatment of various malignancies, e.g., lung or testis cancer, but dosing is limited by nephrotoxicity
(Manohar and Leung, 2017).
CKD group comprised of only CKD in 5 (14.70%) patients, TDF nephrotoxicity
overlapping with CKD in 19 (55.88%) patients and AKI on CKD in 10 (41.66%) patients.
In general, there are many factors that might increase the risk of nephrotoxicity
in patients receiving vancomycin plus PTZ beside the concomitant use of this combination, such as higher doses of vancomycin or PTZ, a high vancomycin trough level, and/or concomitant use of other nephrotoxic medications [8,17-19].
Safirstein, "Cisplatin nephrotoxicity
," Seminars in Nephrology, vol.