nephrotoxicity


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nephrotoxicity

 
the quality of being destructive to kidney cells.

neph·ro·tox·ic·i·ty

(nef'rō-tok-sis'i-tē),
The quality or state of being toxic to kidney cells.

neph·ro·tox·ic·i·ty

(nef'rō-tok-sis'i-tē)
The quality or state of being toxic to kidney cells.

nephrotoxicity

The liability of a substance, such as a drug, to cause damage to the kidneys. A nephrotoxic effect is more likely if existing kidney damage reduces the rate of excretion of the toxic agent so that it acts for longer periods on the kidneys.
References in periodicals archive ?
The following adverse reactions have been reported: nephrotoxicity, ototoxicity, myelosuppression, leukopenia, thrombocytopenia, anemia, fever, infection, nausea, and vomiting.
Given the multiple reports regarding the TDF nephrotoxicity with some countries already switching to TAF, we decided to investigate any toxic effects of TDF in our cohort of Omani patients.
Nephroprotective effect of catechin on gentamicin-induced experimental nephrotoxicity. Clinical and experimental nephrology 2015; 19(2): 178-84.Zhou P, Yu JF, Zhao CG, Sui FX, Teng X, Wu YB.
Nephrotoxicity is another major toxicity caused by cisplatin treatment.
Thus, the widespread use of CDDP in the treatment of various solid tumors in these animals, as well as in humans, is associated with a problematic issue of nephrotoxicity (Knapp et al., 1987, 1988).
Cisplatin is a chemotherapeutic used for treatment of various malignancies, e.g., lung or testis cancer, but dosing is limited by nephrotoxicity (Manohar and Leung, 2017).
CKD group comprised of only CKD in 5 (14.70%) patients, TDF nephrotoxicity overlapping with CKD in 19 (55.88%) patients and AKI on CKD in 10 (41.66%) patients.
In general, there are many factors that might increase the risk of nephrotoxicity in patients receiving vancomycin plus PTZ beside the concomitant use of this combination, such as higher doses of vancomycin or PTZ, a high vancomycin trough level, and/or concomitant use of other nephrotoxic medications [8,17-19].