Aqueous extract of Allium sativum L bulbs offer nephroprotection
by attenuating vascular endothelial growth factor and extracellular signal-regulated kinase-1 expression in diabetic rats.
Although various studies have been reported on the benefits of several agents in cisplatin induced renal toxicity, the basis of nephroprotection remains elusive (Miller etal.
These observations support the hypothesis that the mechanism of nephrotoxicity is related to free radical generation and the nephroprotection offered by hesperidin is due to antioxidant defense system.
The data from the BENEFIT (Belatacept Evaluation of Nephroprotection
and Efficacy as First-line Immunosuppression Trial) trial, recorded 666 kidney transplants at 100 sites around the world.
Ability to improve renal function has been proved in trials but does not have FDA-approved indication for nephroprotection
A novel, potent and selective renin inhibitor, VTP-27999 is designed to offer a best-in-class therapeutic profile - most importantly, improved nephroprotection
The patients, aged 18 years or older, who were expected to receive a kidney transplant from a standard criteria donor were included in BENEFIT (Belatacept Evaluation of Nephroprotection
and Efficacy as First-line Immunosuppression Trial).
The findings suggest that the probable mechanism of nephroprotection by C.
Keywords: Cassia auriculata; Cisplatin; Gentamicin; Nephrotoxicity; Nephroprotection
There is a continuous search for agents which provide nephroprotection against the renal impairment induced by drugs like cisplatin and gentamicin for which allopathy offers no remedial measures.